Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363254 | 1.00 | ACHE (0.46) | ACHEALOX15EPHX1BCHEALDH1A1 | |
| SCHEMBL13871880 | 0.79 | EPHX2 (0.48) | ACHEEPHX1 | |
| SCHEMBL7201459 | 0.76 | ALOX15 (0.64) | ACHEALOX15EPHX1 | |
| SCHEMBL6281516 | 0.76 | ACHE (0.44) | ACHEEPHX1ALDH1A1KMT2A | |
| SCHEMBL10740367 | 0.75 | ACHE (0.53) | ACHEALOX15EPHX1 | |
| SCHEMBL9493065 | 0.74 | ACHE (0.57) | ACHEALOX15EPHX1 | |
| SCHEMBL10972245 | 0.73 | ACHE (0.55) | ACHEALOX15EPHX1ALDH1A1KMT2A | |
| SCHEMBL22372317 | 0.73 | ACHE (0.55) | ACHEALOX15EPHX1 | |
| SCHEMBL9812807 | 0.73 | ACHE (0.55) | ACHEALOX15EPHX1 | |
| SCHEMBL2541337 | 0.72 | ALDH1A1 (0.53) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120330030-A1 | Enantioselective Synthesis of y-amino-a, B-unsuturated carboxylic acid derivatives | ACEMOGLU MURAT (CH) | 2012-12-27 | — | — | US | disclosed |
| US-8288566-B2 | Enantioselective synthesis of γ-amino-αβ-unsaturated carboxylic acid derivatives | NOVARTIS AG (CH) | 2012-10-16 | — | — | US | disclosed |
| US-20110263873-A1 | Enantioselective Synthesis of y-amino-alpha beta-unsaturated carboxylic acid derivatives | NOVARTIS AG (CH) | 2011-10-27 | — | — | US | disclosed |
| EP-2358663-A1 | ENANTIOSELECTIVE SYNTHESIS OF -AMINO- , -UNSATURATED CARBOXYLIC ACID DERIVATIVES | Novartis AG (CH) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010055162-A1 | ENANTIOSELECTIVE SYNTHESIS OF γ-AMINO-α,β-UNSATURATED CARBOXYLIC ACID DERIVATIVES | NOVARTIS AG (CH) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120330030-A1 | Enantioselective Synthesis of y-amino-a, B-unsuturated carboxylic acid derivatives | BCAT1, BCAT2, AADAT | ACHE 3135/4885ALOX15 352/4885EPHX1 1865/4885 |
| US-20110263873-A1 | Enantioselective Synthesis of y-amino-alpha beta-unsaturated carboxylic acid derivatives | BCAT1, BCAT2, AADAT | ACHE 3157/4885ALOX15 63/4885EPHX1 855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.