SCHEMBL2364731

SCHEMBL2364731

O=C(Nc1cc(CCc2ccccc2)ccc1C(=O)O)c1ccc(Cl)cc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRC P12931 1/20 0.58
NPC1 O15118 1/20 0.56
RAB9A P51151 1/20 0.56
PPARG P37231 2/20 0.55
PPARA Q07869 1/20 0.55
GRIK1 P39086 4/20 0.52
POLB P06746 1/20 0.52
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
GAA P10253 1/20 0.50
TP53 P04637 1/20 0.50
RECQL P46063 1/20 0.50
BLM P54132 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
ALDH1A1 P00352 1/20 0.49
MAPT P10636 1/20 0.49
CYP2C19 P33261 1/20 0.49
TSHR P16473 1/20 0.49
CASP1 P29466 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275852 0.90 MEN1 (0.55) NPC1RAB9AGRIK1POLBMEN1
SCHEMBL2274700 0.86 MEN1 (0.55) GRIK1MEN1KMT2ATDP1MAPT
SCHEMBL2273138 0.84 GRIK1 (0.59) GRIK1MEN1KMT2ATDP1MAPT
SCHEMBL1308769 0.84 PPARG (0.69) NPC1RAB9APPARGPPARAGRIK1
SCHEMBL2271168 0.84 ACLY (0.67) GRIK1MEN1KMT2ARECQLBLM
SCHEMBL2269795 0.84 SLC16A3 (0.55) NPC1RAB9AGRIK1MEN1KMT2A
SCHEMBL2891026 0.83 PPARG (0.68) NPC1RAB9APPARGPPARAGRIK1
SCHEMBL2274007 0.82 GRIK1 (0.57) NPC1RAB9AGRIK1MEN1KMT2A
SCHEMBL2270227 0.81 SLC16A3 (0.58) NPC1RAB9AMEN1KMT2ARECQL
SCHEMBL2275929 0.81 KMT2A (0.62) GRIK1MEN1KMT2ATDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 SRC 604/4885NPC1 4836/4885RAB9A 2238/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.