Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.42 |
| ▸ | F12 | P00748 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.38 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28818366 | 0.89 | P2RX7 (0.41) | ALDH1A1HPGDHSD17B10P2RX7PIK3CD | |
| SCHEMBL23648657 | 0.86 | ALDH1A1 (0.46) | ALDH1A1HPGDHSD17B10TSHRP2RX7 | |
| SCHEMBL29871289 | 0.86 | ALDH1A1 (0.46) | ALDH1A1HPGDHSD17B10TSHRP2RX7 | |
| SCHEMBL29870905 | 0.85 | ALDH1A1 (0.45) | ALDH1A1HPGDHSD17B10P2RX7F12 | |
| SCHEMBL23648608 | 0.85 | ALDH1A1 (0.45) | ALDH1A1HPGDHSD17B10P2RX7F12 | |
| SCHEMBL29870825 | 0.85 | HSD17B10 (0.41) | ALDH1A1HPGDHSD17B10TSHRP2RX7 | |
| SCHEMBL23648614 | 0.85 | HSD17B10 (0.41) | ALDH1A1HPGDHSD17B10TSHRP2RX7 | |
| SCHEMBL23656497 | 0.82 | P2RX7 (0.48) | ALDH1A1HPGDHSD17B10TSHRP2RX7 | |
| SCHEMBL24750777 | 0.82 | ALDH1A1 (0.58) | ALDH1A1HSD17B10 | |
| SCHEMBL23656488 | 0.82 | ALDH1A1 (0.52) | ALDH1A1HPGDHSD17B10USP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114945561-A | Novel pyrazole derivatives | 阿普塔生物治疗公司 | 2022-08-26 | — | — | CN | claimed |
| WO-2021145655-A1 | NOVEL PYRAZOLE DERIVATIVE | 압타바이오 주식회사 | 2021-07-22 | — | — | WO | claimed |
| US-12509438-B2 | Pyrazole derivative | APTABIO THERAPEUTICS INC. (KR) | 2025-12-30 | — | — | US | disclosed |
| US-20230067461-A1 | NOVEL PYRAZOLE DERIVATIVE | APTABIO THERAPEUTICS INC. (KR) | 2023-03-02 | — | — | US | disclosed |
| US-20230067461-A1 | NOVEL PYRAZOLE DERIVATIVE | APTABIO THERAPEUTICS INC. (KR) | 2023-03-02 | — | — | US | disclosed |
| EP-4105206-A1 | NOVEL PYRAZOLE DERIVATIVE | Aptabio Therapeutics Inc. (KR) | 2022-12-21 | — | — | EP | disclosed |
| CN-114945561-A | Novel pyrazole derivatives | 阿普塔生物治疗公司 | 2022-08-26 | — | — | CN | disclosed |
| WO-2021145655-A1 | NOVEL PYRAZOLE DERIVATIVE | 압타바이오 주식회사 | 2021-07-22 | — | — | WO | disclosed |
| WO-2021145655-A1 | NOVEL PYRAZOLE DERIVATIVE | 압타바이오 주식회사 | 2021-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12509438-B2 | Pyrazole derivative | CBR3, NR3C2, NR3C1 | ALDH1A1 769/4885HPGD 1765/4885HSD17B10 445/4885 |
| US-20230067461-A1 | NOVEL PYRAZOLE DERIVATIVE | CYP3A5, CYP3A7, CYP3A4 | ALDH1A1 507/4885HPGD 1365/4885HSD17B10 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.