Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.49 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | GHSR | Q92847 | 2/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171526 | 0.87 | UTS2R (0.47) | HTR6BRD4CREBBPUTS2RTP53 | |
| SCHEMBL2170956 | 0.86 | BRD4 (0.41) | HTR6BRD4BRD2UTS2R | |
| SCHEMBL2173430 | 0.86 | HTR6 (0.48) | HTR6GHSRALDH1A1MEN1KMT2A | |
| SCHEMBL2231550 | 0.82 | PPARG (0.49) | HTR6BRD4TP53SMN1; SMN2 | |
| SCHEMBL2169880 | 0.81 | HTR6 (0.41) | HTR6BRD4GHSRBRD2ALDH1A1 | |
| SCHEMBL2171351 | 0.80 | LMNA (0.52) | HTR6GHSRPKMALDH1A1MEN1 | |
| SCHEMBL2170726 | 0.77 | HTR6 (0.49) | HTR6BRD4PKMALDH1A1MEN1 | |
| SCHEMBL2170559 | 0.76 | SLC22A12 (0.47) | HTR6BRD4ALDH1A1MEN1KMT2A | |
| SCHEMBL2171757 | 0.76 | ESR1 (0.47) | BRD4PKMALDH1A1MEN1KMT2A | |
| SCHEMBL2171321 | 0.75 | MEN1 (0.46) | HTR6ALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | claimed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | claimed |