Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 3/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966471 | 0.81 | TP53 (0.51) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL19026636 | 0.79 | TP53 (0.50) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL7969008 | 0.75 | TP53 (0.50) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL7965870 | 0.73 | REN (0.51) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL8678455 | 0.73 | TSHR (0.55) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL8323180 | 0.73 | TSHR (0.55) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL444104 | 0.73 | TSHR (0.55) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL10667108 | 0.73 | TSHR (0.55) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL9296848 | 0.73 | TSHR (0.55) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL8840559 | 0.73 | TSHR (0.55) | TP53TSHREBPSIGMAR1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364293-B1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| EP-2364293-B1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| US-8258169-B2 | Pyrazole-4-N-alkoxycarboxamides as microbiocides | SYNGENTA CROP PROTECTION, LLC (US) | 2012-09-04 | — | — | US | disclosed |
| US-8258169-B2 | Pyrazole-4-N-alkoxycarboxamides as microbiocides | SYNGENTA CROP PROTECTION, LLC (US) | 2012-09-04 | — | — | US | disclosed |
| US-8258169-B2 | Pyrazole-4-N-alkoxycarboxamides as microbiocides | SYNGENTA CROP PROTECTION, LLC (US) | 2012-09-04 | — | — | US | disclosed |
| US-20110230537-A1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | SYNGENTA CROP PROTECTION LLC (US) | 2011-09-22 | — | — | US | disclosed |
| US-20110230537-A1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | SYNGENTA CROP PROTECTION LLC (US) | 2011-09-22 | — | — | US | disclosed |
| US-20110230537-A1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | SYNGENTA CROP PROTECTION LLC (US) | 2011-09-22 | — | — | US | disclosed |
| EP-2364293-A2 | NOVEL MICROBIOCIDES | Syngenta Participations AG (CH) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010063700-A2 | NOVEL MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-10 | — | — | WO | disclosed |
| WO-2010063700-A2 | NOVEL MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230537-A1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | CASP1, CASP14, CD14 | TP53 3773/4885TSHR 4062/4885EBP 1057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.