Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | EBP | Q15125 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 3/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19026636 | 0.84 | TP53 (0.50) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL2367040 | 0.81 | TP53 (0.47) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL7969008 | 0.80 | TP53 (0.50) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL7965870 | 0.77 | REN (0.51) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL23986713 | 0.77 | TAAR1 (0.59) | TP53TSHRSIGMAR1ACACB | |
| SCHEMBL7969024 | 0.77 | CYP3A4 (0.42) | ACACBKCNH2 | |
| SCHEMBL9883275 | 0.77 | SLC6A2 (0.53) | ACACB | |
| SCHEMBL9296848 | 0.77 | TSHR (0.55) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL10667108 | 0.77 | TSHR (0.55) | TP53TSHREBPSIGMAR1ACACB | |
| SCHEMBL8678455 | 0.77 | TSHR (0.55) | TP53TSHREBPSIGMAR1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200087730-A1 | METHODS OF IDENTIFYING AND TREATING TUMORS WITH SIGMA1 INHIBITORS | UNIV DREXEL (US) | 2020-03-19 | — | — | US | disclosed |
| WO-2017106312-A1 | METHODS OF MODULATING LEVELS OF IL-6 AND PD-L1 | DREXEL UNIVERSITY (US) | 2017-06-22 | — | — | WO | disclosed |
| US-20160361279-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | Philadelphia Health And Education Corporation, d/b/a Drexel University College of Medicine | 2016-12-15 | — | — | US | disclosed |
| US-9388126-B2 | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same | DREXEL UNIVERSITY (US) | 2016-07-12 | — | — | US | disclosed |
| US-20150166472-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | DREXEL UNIVERSITY | 2015-06-18 | — | — | US | disclosed |
| US-6271385-B1 | FUNGICIDES (SUCH AS THOSE FOR USE IN FARMING AND HORTICULTURE). | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2001-08-07 | — | — | US | disclosed |
| EP-1020441-A1 | N-HETEROCYCLIC METHYLPROPYLAMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND GERMICIDES | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2000-07-19 | — | — | EP | disclosed |
| US-4914133-A | CONTROLLING PHYTOPATHOGENS | BASF AKTIENGESELLSCHAFT (DE) | 1990-04-03 | — | — | US | disclosed |
| EP-0288850-A1 | Amino compounds and fungicides containing them | BASF Aktiengesellschaft (DE) | 1988-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166472-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | TMEM97, SIGMAR1, ADRM1 | TP53 3084/4885TSHR 1366/4885EBP 650/4885 |
| US-20200087730-A1 | METHODS OF IDENTIFYING AND TREATING TUMORS WITH SIGMA1 INHIBITORS | SIGMAR1, TMEM97, OPRK1 | TP53 1713/4885TSHR 1278/4885EBP 980/4885 |
| US-20160361279-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | TMEM97, SIGMAR1, ADRM1 | TP53 3113/4885TSHR 1404/4885EBP 632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.