Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.38 |
| ▸ | NQO2 | P16083 | 7/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14480255 | 0.79 | HTR2C (0.41) | KDM1AHTR2CHTR2AHTR2BMTNR1A | |
| SCHEMBL6653153 | 0.73 | HTR2C (0.38) | ESR1ESR2HTR2CHTR2A | |
| SCHEMBL29051650 | 0.71 | HTR2C (0.53) | KDM1AHTR2CHTR2AHTR2B | |
| SCHEMBL30468465 | 0.70 | ADRA2A (0.49) | KDM1AHTR2CHTR2AHTR2B | |
| SCHEMBL6651372 | 0.69 | HTR2C (0.48) | KDM1AHTR2CHTR2AHTR2B | |
| SCHEMBL1904887 | 0.69 | HTR2C (0.48) | KDM1AHTR2CHTR2AHTR2B | |
| SCHEMBL2365631 | 0.67 | DRD2 (0.40) | ESR1ESR2HTR2CHTR2A | |
| SCHEMBL3862896 | 0.67 | MTNR1A (0.43) | ESR1ESR2KDM1AMTNR1AMTNR1B | |
| SCHEMBL6655706 | 0.66 | HTR2C (0.48) | KDM1AHTR2CHTR2AHTR2B | |
| SCHEMBL3867164 | 0.66 | MTNR1A (0.42) | ESR1ESR2MTNR1AMTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2363394-A1 | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its salts, solvates or hydrates and its use for the treatment of CNS disorders | Arena Pharmaceuticals, Inc. (US) | 2011-09-07 | — | — | EP | disclosed |
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |