Sugi Predict

Sugi Predict / Compounds / SCHEMBL2368837

SCHEMBL2368837

SCHEMBL2368837

ClP(Cl)c1cccc2ccccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 5/20 0.48
▸ CYP2A6 P11509 4/20 0.48
▸ ALDH1A1 P00352 8/20 0.46
▸ HSD17B10 Q99714 5/20 0.46
▸ TSHR P16473 3/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ HPGD P15428 3/20 0.42
▸ CYP3A4 P08684 2/20 0.42
▸ KEAP1 Q14145 1/20 0.42
▸ HPRT1 P00492 1/20 0.42
▸ PAX8 Q06710 1/20 0.39
▸ HIF1A Q16665 1/20 0.39
▸ CYP1B1 Q16678 1/20 0.39
▸ THRB P10828 1/20 0.39
▸ CYP2C9 P11712 2/20 0.38
▸ CYP2C19 P33261 2/20 0.38
▸ NR4A1 P22736 1/20 0.37
▸ NR4A2 P43354 1/20 0.37
▸ NR4A3 Q92570 1/20 0.37
▸ CA9 Q16790 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2516404 0.85 CYP1A2 (0.48) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL517685 0.81 ALDH1A1 (0.53) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL9327630 0.81 CYP1A2 (0.44) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL11418253 0.79 ALDH1A1 (0.41) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL29390280 0.79 ALDH1A1 (0.50) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL135987 0.79 ALDH1A1 (0.50) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL3277146 0.78 CYP2A6 (0.41) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL15658735 0.77 ALDH1A1 (0.48) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL11861469 0.77 ALDH1A1 (0.48) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL11826715 0.77 ALDH1A1 (0.48) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1354886-B1 Process for the preparation of tertiary phosphines SALTIGO GMBH (DE) 2009-08-26 — — EP claimed
US-7230136-B2 Reacting phosphorus halide with organomagnesium compound in presence of copper compound LANXESS DEUTSCHLAND GMBH (DE) 2007-06-12 — — US claimed
US-20030229240-A1 Reacting phosphorus halide with organomagnesium compound in presence of copper compound LANXESS DEUTSCHLAND GMBH (DE) 2003-12-11 — — US claimed
EP-1354886-A1 Process for the preparation of tertiary phosphines Bayer Aktiengesellschaft (DE) 2003-10-22 — — EP claimed
EP-1669398-B1 FLAME-RETARDANT PROCESSED RESIN OBTAINED WITH A REACTIVE FLAME RETARDANT FUJI ELECTRIC CO LTD (JP) 2014-01-08 — — EP disclosed
CN-101490065-B Method for producing organic phosphorous compounds containing halogene BASF SE 2013-06-19 — — CN disclosed
CN-101831083-B Reactive flame retardant and flame-retardant resin processed article FUJI ELECTRIC CO LTD 2012-07-18 — — CN disclosed
EP-2044092-B1 METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE BASF SE (DE) 2011-09-28 — — EP disclosed
US-7851656-B2 Method for producing organic phosphorous compounds containing halogens BASF SE (DE) 2010-12-14 — — US disclosed
US-7847126-B2 prepared by reacting phosphorus halide with organomagnesium compound in presence of copper compound; di(tert-butyl)phenylphosphonium tetrafluoroborate, for example LANXESS DEUTSCHLAND GMBH (DE) 2010-12-07 — — US disclosed
CN-101831083-A Reactive flame retardant and flame-retardant resin processed article FUJI ELECTRIC HOLDINGS 2010-09-15 — — CN disclosed
US-20090281356-A1 METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE BASF SE (DE) 2009-11-12 — — US disclosed
US-4263231-A REACTING DICHLOROPHOSPHANES AND 2-N-ACYLAMINOPHENOLS HOECHST AKTIENGESELLSCHAFT (DE) 1981-04-21 — — US disclosed
US-4247488-A Process for the preparation of 1-oxophosphol-Δ3 -enes HOECHST AKTIENGESELLSCHAFT (DE) 1981-01-27 — — US disclosed
US-RE30279-E FROM ALKYL OR ARYL HALIDE WITH HALO-SUBSTITUTED TRIVALENT PHOSPHORUS COMPOUNDS AND PHOSPHORUS PENTASULFIDE OR -OXIDE STAUFFER CHEMICAL COMPANY (US) 1980-05-20 — — US disclosed
EP-0006220-A1 Process for the preparation of 3-Acyl-2-alkyl(aryl)-1.3.2-benzoxazaphospholanes HOECHST AKTIENGESELLSCHAFT (DE) 1980-01-09 — — EP disclosed
EP-0006195-A1 Process for preparing delta-3 1-oxophospholenes HOECHST AKTIENGESELLSCHAFT (DE) 1980-01-09 — — EP disclosed
US-4080377-A Production of cyclic five-membered ring unsaturated phosphine dichlorides BAYER AKTIENGESELLSCHAFT (DT) 1978-03-21 — — US disclosed
US-4022808-A ZINC-ALUMINUM-TITANIUM-TIN-IRON OR GROUP 5A AS CATALYSTS NIPPON SODA COMPANY LIMITED (JA) 1977-05-10 — — US disclosed
US-3932566-A Phosphonate polymers CELANESE CORPORATION (US) 1976-01-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090281356-A1 METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE PRXL2A, XRN2, POLR2B CYP1A2 428/4885CYP2A6 2111/4885ALDH1A1 4453/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.