Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28282196 | 0.86 | HTR6 (0.45) | L3MBTL1PKMHTTALDH1A1MEN1 | |
| SCHEMBL28733500 | 0.85 | HTT (0.47) | CA2L3MBTL1PKMHTTALDH1A1 | |
| SCHEMBL5768468 | 0.76 | CA1 (0.47) | CA1CA2RAPGEF4L3MBTL1PKM | |
| SCHEMBL12359763 | 0.74 | HTR6 (0.58) | L3MBTL1HTTALDH1A1MEN1KMT2A | |
| SCHEMBL8962760 | 0.73 | LMNA (0.44) | CA1CA2RAPGEF4L3MBTL1PKM | |
| SCHEMBL30877454 | 0.73 | RAPGEF4 (0.47) | CA1CA2RAPGEF4L3MBTL1PKM | |
| SCHEMBL12612442 | 0.72 | RAPGEF4 (0.56) | CA1CA2RAPGEF4L3MBTL1PKM | |
| SCHEMBL23762156 | 0.70 | L3MBTL1 (0.46) | L3MBTL1PKMALDH1A1HSD11B1MEN1 | |
| SCHEMBL23120015 | 0.70 | L3MBTL1 (0.46) | CA1CA2RAPGEF4L3MBTL1PKM | |
| SCHEMBL4277234 | 0.70 | L3MBTL1 (0.49) | CA1CA2RAPGEF4L3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024041586-A1 | PRODRUG OF JAK KINASE INHIBITOR | 启元生物(杭州)有限公司 | 2024-02-29 | — | — | WO | disclosed |
| CN-115403594-A | Nitrogen-containing tricyclic compound and application thereof | 正大天晴药业集团股份有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-114728967-A | Tri-heterocyclic compounds as JAK inhibitors and application thereof | 正大天晴药业集团股份有限公司 | 2022-07-08 | — | — | CN | disclosed |
| EP-3856742-A1 | TRICYCLIC JANUS KINASE 1 INHIBITORS, AND COMPOSITIONS AND METHODS THEREOF | Lynk Pharmaceuticals Co. Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |
| CN-110483514-A | The ring hydrazine derivate and its application that a kind of cyano replaces | VIVAVISION BIOPHARMA SHANGHAI CO LTD | 2019-11-22 | — | — | CN | disclosed |
| CN-106336413-A | Compounds used as JAK inhibitor, and use of compounds | 广东东阳光药业有限公司 | 2017-01-18 | — | — | CN | disclosed |