Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | UBE2M | P61081 | 7/20 | 0.57 |
| ▸ | DCUN1D1 | Q96GG9 | 7/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23200060 | 0.84 | UBE2M (0.67) | ALDH1A1UBE2MDCUN1D1TSHRTP53 | |
| SCHEMBL23200068 | 0.81 | ALDH1A1 (0.54) | ALDH1A1TSHRTP53THRBLMNA | |
| SCHEMBL23200048 | 0.81 | ALDH1A1 (0.61) | ALDH1A1UBE2MDCUN1D1TP53LMNA | |
| SCHEMBL3482704 | 0.80 | ALDH1A1 (0.62) | ALDH1A1TP53NPSR1ATMUSP2 | |
| SCHEMBL23699889 | 0.79 | ALDH1A1 (0.62) | ALDH1A1UBE2MDCUN1D1TP53LMNA | |
| SCHEMBL23200025 | 0.79 | UBE2M (0.60) | ALDH1A1UBE2MDCUN1D1TP53LMNA | |
| SCHEMBL23200067 | 0.78 | ALDH1A1 (0.57) | ALDH1A1UBE2MDCUN1D1TP53LMNA | |
| SCHEMBL23199954 | 0.78 | ALDH1A1 (0.57) | ALDH1A1UBE2MDCUN1D1TP53LMNA | |
| SCHEMBL23200239 | 0.78 | ALDH1A1 (1.00) | ALDH1A1TSHRTP53THRBLMNA | |
| SCHEMBL9256017 | 0.77 | ALDH1A1 (0.66) | ALDH1A1UBE2MDCUN1D1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238139-A1 | MODULATORS OF TRYPTOPHAN CATABOLISM | E-THERAPEUTICS PLC (GB) | 2021-08-05 | — | — | US | claimed |
| US-20210238139-A1 | MODULATORS OF TRYPTOPHAN CATABOLISM | E-THERAPEUTICS PLC (GB) | 2021-08-05 | — | — | US | disclosed |
| US-20210238139-A1 | MODULATORS OF TRYPTOPHAN CATABOLISM | E-THERAPEUTICS PLC (GB) | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238139-A1 | MODULATORS OF TRYPTOPHAN CATABOLISM | TPH1, KYNU, TPH2 | ALDH1A1 606/4885UBE2M 3929/4885DCUN1D1 1039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.