Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | PTGFR | P43088 | 5/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372605 | 0.91 | DHODH (0.53) | DHODHTRPV4NR1I2PTGFRPPARG | |
| SCHEMBL2373263 | 0.90 | TRPV4 (0.49) | DHODHTRPV4KDM4EGAANR1I2 | |
| SCHEMBL2372779 | 0.90 | TRPV4 (0.45) | TRPV4NR1I2CACNA1FCACNA1DCACNA1S | |
| SCHEMBL2374017 | 0.88 | DHODH (0.45) | DHODHTRPV4KDM4EGAANR1I2 | |
| SCHEMBL2372822 | 0.88 | DHODH (0.49) | DHODHTRPV4KDM4EGAAPTGFR | |
| SCHEMBL2372609 | 0.83 | DHODH (0.53) | DHODHTRPV4KDM4EGAANR1I2 | |
| SCHEMBL2372769 | 0.82 | PTGFR (0.54) | DHODHTRPV4KDM4EPTGFR | |
| SCHEMBL2373092 | 0.82 | KDM4E (0.56) | DHODHKDM4EGAAPTGFR | |
| SCHEMBL2373011 | 0.82 | DHODH (0.58) | DHODHTRPV4KDM4EGAAPTGFR | |
| SCHEMBL2372055 | 0.81 | DHODH (0.54) | DHODHKDM4EGAAPTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |