Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | PTGFR | P43088 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373263 | 0.93 | TRPV4 (0.49) | DHODHPPARGPPARAKDM4EGAA | |
| SCHEMBL2373047 | 0.91 | DHODH (0.54) | DHODHTRPV4NR1I2PTGFRESR1 | |
| SCHEMBL2373069 | 0.89 | TRPV4 (0.46) | PPARGPPARATRPV4NR1I2MAPT | |
| SCHEMBL2372822 | 0.89 | DHODH (0.49) | DHODHKDM4EGAATRPV4PTGFR | |
| SCHEMBL2371969 | 0.88 | DHODH (0.44) | DHODHPPARGPPARAKDM4EGAA | |
| SCHEMBL2372609 | 0.85 | DHODH (0.53) | DHODHKDM4EGAATRPV4NR1I2 | |
| SCHEMBL2372420 | 0.85 | KDM4E (0.46) | DHODHKDM4EGAAPTGFRMAPT | |
| SCHEMBL2372758 | 0.83 | DHODH (0.56) | DHODHTRPV4NR1I2PTGFR | |
| SCHEMBL2372769 | 0.83 | PTGFR (0.54) | DHODHKDM4ETRPV4PTGFRALDH1A1 | |
| SCHEMBL2373092 | 0.83 | KDM4E (0.56) | DHODHKDM4EGAAPTGFRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |