Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23726552 | 0.85 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTRAB9ANPC1 | |
| SCHEMBL14802285 | 0.74 | KDM4E (0.45) | HTR6ALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL23293605 | 0.72 | KDM5A (0.55) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL31609642 | 0.71 | RAB9A (0.58) | ALDH1A1KDM4EMAPTRAB9ANPC1 | |
| SCHEMBL7920033 | 0.71 | RAB9A (0.58) | ALDH1A1KDM4EMAPTRAB9ANPC1 | |
| SCHEMBL23725058 | 0.70 | ALOX15 (0.44) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL3881195 | 0.70 | KDM4E (0.45) | HTR6ALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL23725416 | 0.70 | ADRB2 (0.31) | — | |
| SCHEMBL23726042 | 0.69 | — | — | |
| SCHEMBL29725548 | 0.68 | GABRA1 (0.60) | ALDH1A1KDM4EMAPTTP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |