Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GUSB | P08236 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | CASR | P41180 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14141938 | 0.92 | HDAC6 (0.51) | PTGESKDM4EHPGDHSD17B10GUSB | |
| SCHEMBL5508220 | 0.84 | KDM4E (0.55) | PTGESKDM4EHPGDHSD17B10GUSB | |
| SCHEMBL3111166 | 0.83 | KDM4E (0.59) | PTGESKDM4EHPGDHSD17B10GUSB | |
| SCHEMBL31722934 | 0.83 | KDM4E (0.59) | PTGESKDM4EHPGDHSD17B10GUSB | |
| SCHEMBL7393988 | 0.80 | F7 (0.55) | PTGESKDM4EHPGDHSD17B10GUSB | |
| SCHEMBL11243512 | 0.78 | GUSB (0.70) | KDM4EHPGDHSD17B10GUSBPDE5A | |
| SCHEMBL7393993 | 0.77 | AMY1A (0.64) | KDM4EHPGDHSD17B10GUSBMEN1 | |
| SCHEMBL9010824 | 0.76 | PTGES (0.39) | PTGESKDM4EHPGDHSD17B10FLT3 | |
| SCHEMBL30918933 | 0.74 | LMNA (0.53) | PTGESKDM4EHPGDHSD17B10FLT3 | |
| SCHEMBL7396100 | 0.71 | AMY1A (0.64) | KDM4EHPGDHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366696-A1 | Process for producing 4-aminoquinazolines | Vertex Pharmaceuticals Incorporated (US) | 2011-09-21 | — | — | EP | claimed |
| EP-1828150-A2 | PROCESSES FOR PRODUCING 4-AMINOQUINAZOLINES | Vertex Pharmaceuticals Incorporated (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006066044-A2 | PROCESSES FOR PRODUCING 4-AMINOQUINAZOLINES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-06-22 | — | — | WO | disclosed |