Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DTYMK | P23919 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | SELL | P14151 | 1/20 | 0.42 |
| ▸ | SELP | P16109 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15622 | 0.98 | DTYMK (0.49) | DTYMKGPR35TSHRCASP6SELL | |
| Ammonia Solution, Strong SCHEMBL2373499 | 0.96 | DTYMK (0.47) | DTYMKGPR35TSHRCASP6SELL | |
| SCHEMBL2373328 | 0.96 | DTYMK (0.47) | DTYMKGPR35TSHRCASP6SELL | |
| SCHEMBL15557230 | 0.96 | DTYMK (0.47) | DTYMKGPR35TSHRCASP6SELL | |
| SCHEMBL2373299 | 0.96 | DTYMK (0.47) | DTYMKGPR35TSHRCASP6SELL | |
| SCHEMBL1355971 | 0.85 | GPR35 (0.50) | DTYMKGPR35TSHRCASP6ALDH1A1 | |
| SCHEMBL304470 | 0.85 | CASP6 (0.55) | DTYMKGPR35TSHRCASP6ALDH1A1 | |
| SCHEMBL1981517 | 0.83 | GPR35 (0.52) | DTYMKGPR35TSHRCASP6SELL | |
| SCHEMBL27501298 | 0.83 | CASP6 (0.53) | DTYMKGPR35TSHRCASP6ALDH1A1 | |
| SCHEMBL537538 | 0.80 | DTYMK (0.49) | DTYMKGPR35TSHRCASP6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130153098-A1 | Gas Generant Compositions | JOYSON SAFETY SYSTEMS ACQUISITION LLC | 2013-06-20 | — | — | US | claimed |
| WO-2011119240-A1 | GAS GENERANT COMPOSITIONS | GANTA SUDHAKAR R (US) | 2011-09-29 | — | — | WO | claimed |
| WO-2014197508-A1 | NITRO AROMATIC SUBSTITUTED METAL HYDROXYL NITRATES | TK HOLDINGS INC. (US) | 2014-12-11 | — | — | WO | disclosed |
| US-20140352855-A1 | Nitro Aromatic Substituted Metal Hydroxyl Nitrates | TK HOLDINGS INC. (US) | 2014-12-04 | — | — | US | disclosed |
| US-20130153098-A1 | Gas Generant Compositions | JOYSON SAFETY SYSTEMS ACQUISITION LLC | 2013-06-20 | — | — | US | disclosed |
| US-20130068354-A1 | Gas Generant Manufacturing Method | TK HOLDINGS, INC. | 2013-03-21 | — | — | US | disclosed |
| WO-2011119241-A1 | GAS GENERANT MANUFACTURING METHOD | DOMAZET, SLAVEN (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119240-A1 | GAS GENERANT COMPOSITIONS | GANTA SUDHAKAR R (US) | 2011-09-29 | — | — | WO | disclosed |