Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 10/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373287 | 0.93 | TRPV4 (0.52) | TRPV4NR1I2PPARGPPARAMAPT | |
| SCHEMBL2372251 | 0.90 | TRPV4 (0.51) | TRPV4NR1I2MAPTTDP1PLA2G2A | |
| SCHEMBL2374017 | 0.89 | DHODH (0.45) | TRPV4NR1I2PPARGPPARAALDH1A1 | |
| SCHEMBL2372779 | 0.89 | TRPV4 (0.45) | TRPV4NR1I2PPARGPPARATDP1 | |
| SCHEMBL2373216 | 0.84 | LMNA (0.51) | TRPV4MAPTLMNAPLA2G2AHTT | |
| SCHEMBL2372559 | 0.84 | TRPV4 (0.50) | TRPV4 | |
| SCHEMBL2372172 | 0.83 | PLA2G2A (0.51) | TRPV4ALDH1A1TDP1PLA2G2AHTT | |
| SCHEMBL2373306 | 0.82 | DHODH (0.51) | TRPV4ALDH1A1PLA2G2AHTT | |
| SCHEMBL2372047 | 0.82 | PTGS2 (0.43) | TRPV4NR1I2 | |
| SCHEMBL2373263 | 0.82 | TRPV4 (0.49) | TRPV4NR1I2PPARGPPARAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |