Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | CASR | P41180 | 3/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23732388 | 1.00 | LOXL2 (0.48) | LOXL2CASRCYP4F2CYP4A11RAB9A | |
| SCHEMBL23746338 | 1.00 | LOXL2 (0.48) | LOXL2CASRCYP4F2CYP4A11RAB9A | |
| SCHEMBL31226811 | 1.00 | LOXL2 (0.48) | LOXL2CASRCYP4F2CYP4A11RAB9A | |
| SCHEMBL3182845 | 0.87 | CYP4F2 (0.55) | LOXL2CASRCYP4F2CYP4A11RAB9A | |
| SCHEMBL31226962 | 0.85 | LOXL2 (0.51) | LOXL2CASRCYP4F2CYP4A11RAB9A | |
| SCHEMBL27823837 | 0.85 | LOXL2 (0.48) | LOXL2CASRCYP4F2CYP4A11ADRB2 | |
| SCHEMBL9359858 | 0.83 | CYP4F2 (0.54) | LOXL2CASRCYP4F2CYP4A11RAB9A | |
| SCHEMBL5662355 | 0.83 | LOXL2 (0.51) | LOXL2CASRCYP4F2CYP4A11RAB9A | |
| SCHEMBL4794922 | 0.83 | LTB4R (0.51) | LOXL2CASRCYP4F2CYP4A11 | |
| SCHEMBL6330723 | 0.82 | LOXL2 (0.58) | LOXL2CASRCYP4F2CYP4A11RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12629374-B2 | Antimalarial agents | MERCK SHARP & DOHME LLC (US) | 2026-05-19 | — | — | US | disclosed |
| US-20230139282-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME LLC (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230139282-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME LLC (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230139282-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME LLC (US) | 2023-05-04 | — | — | US | disclosed |
| WO-2021155791-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2021-08-12 | — | — | WO | disclosed |
| WO-2021155612-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230139282-A1 | ANTIMALARIAL AGENTS | G6PD, MTX1, OAT | LOXL2 3649/4885CASR 4588/4885CYP4F2 279/4885 |
| US-12629374-B2 | Antimalarial agents | CLIC1, CYC1, HCCS | LOXL2 2918/4885CASR 3175/4885CYP4F2 623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.