Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 11/20 | 0.43 |
| ▸ | EIF2AK3 | Q9NZJ5 | 8/20 | 0.43 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.42 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870211 | 0.85 | BRD4 (0.45) | KDRFLT3RIPK1EIF2AK3EIF2AK2 | |
| SCHEMBL27975782 | 0.79 | RIPK1 (0.58) | RIPK1EIF2AK3EIF2AK2EIF2AK1 | |
| SCHEMBL868611 | 0.79 | RIPK1 (0.67) | KDRFLT3RIPK1EIF2AK3EIF2AK2 | |
| SCHEMBL2373645 | 0.77 | RIPK1 (0.68) | RIPK1EIF2AK3 | |
| SCHEMBL868181 | 0.77 | EIF2AK3 (0.66) | KDRFLT3RIPK1EIF2AK3EIF2AK2 | |
| SCHEMBL2373601 | 0.76 | EIF2AK3 (0.61) | KDRRIPK1EIF2AK3EIF2AK1 | |
| SCHEMBL2375097 | 0.76 | EIF2AK3 (0.65) | KDREIF2AK3EIF2AK2EIF2AK1 | |
| SCHEMBL2373579 | 0.75 | RORC (0.40) | RIPK1EIF2AK3CYP11B1CYP11B2 | |
| SCHEMBL2373042 | 0.74 | EIF2AK3 (0.43) | RIPK1EIF2AK3EIF2AK2EIF2AK1 | |
| SCHEMBL2373819 | 0.71 | ABHD6 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |