Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | SMAD2 | Q15796 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | PFKFB3 | Q16875 | 6/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143115 | 0.76 | GPR84 (0.41) | DYRK1ARIPK1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL4137823 | 0.76 | GPR84 (0.41) | DYRK1ARIPK1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL30774560 | 0.73 | BRD4 (0.46) | DYRK1ARIPK1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL31214345 | 0.73 | DYRK1A (0.72) | DYRK1ARIPK1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL13394547 | 0.70 | NPC1 (0.50) | DYRK1ATGFBR1APPNPC1 | |
| SCHEMBL2461409 | 0.69 | DYRK1A (0.50) | DYRK1ARIPK1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL2457852 | 0.69 | PFKFB3 (0.55) | DYRK1ARIPK1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL2457178 | 0.69 | DYRK1A (0.54) | DYRK1ARIPK1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL2458769 | 0.68 | RIPK1 (0.50) | DYRK1ARIPK1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL21871435 | 0.68 | DYRK1A (0.49) | DYRK1ARIPK1TGFBR1BMPR1ASMAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11547701-B2 | Compounds and compositions for the inhibition of NAMPT | VALO HEALTH, INC. (US) | 2023-01-10 | — | — | US | disclosed |
| US-20210244717-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Valo Health, LLC | 2021-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11547701-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NQO1 | DYRK1A 4838/4885RIPK1 1817/4885TGFBR1 4825/4885 |
| US-20210244717-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NQO1 | DYRK1A 4847/4885RIPK1 1529/4885TGFBR1 4819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.