Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30965486 | 1.00 | MAPT (0.44) | MAPTTP53CASP3NPC1RAB9A | |
| SCHEMBL23748369 | 0.87 | RAB9A (0.56) | MAPTTP53CASP3NPC1RAB9A | |
| SCHEMBL30965467 | 0.87 | RAB9A (0.56) | MAPTTP53CASP3NPC1RAB9A | |
| SCHEMBL23748362 | 0.83 | CASP3 (0.59) | MAPTTP53CASP3NPC1RAB9A | |
| SCHEMBL30965495 | 0.82 | NPC1 (0.47) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL25045581 | 0.82 | NPC1 (0.47) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL30965476 | 0.82 | CASP3 (0.58) | MAPTTP53CASP3NPC1RAB9A | |
| SCHEMBL24106590 | 0.82 | CASP3 (0.58) | MAPTTP53CASP3NPC1RAB9A | |
| SCHEMBL23748364 | 0.74 | CASP3 (0.72) | MAPTTP53CASP3NPC1RAB9A | |
| SCHEMBL23748380 | 0.73 | CASP3 (0.71) | MAPTTP53CASP3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113195084-B | Benzoxazoles and related compounds useful as modulators of chaperone mediated autophagy | 阿尔伯爱因斯坦医学院 | 2024-04-09 | — | — | CN | claimed |
| US-20210387953-A1 | BENZOXAZOLE AND RELATED COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2021-12-16 | — | — | US | claimed |
| EP-3863755-A1 | BENZOXAZOLE AND RELATED COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | Albert Einstein College of Medicine (US) | 2021-08-18 | — | — | EP | claimed |
| CN-113195084-A | Benzoxazoles and related compounds useful as modulators of molecular chaperone-mediated autophagy | 阿尔伯爱因斯坦医学院 | 2021-07-30 | — | — | CN | claimed |
| US-20240156872-A1 | Use of Chaperone-Mediated Autophagy Activators For Treating Or Preventing Blood Cancers And Myelodysplastic Syndromes And Enriching Hematopoietic Stem Cell Populations | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2024-05-16 | — | — | US | disclosed |
| WO-2023018801-A1 | COMPOSITIONS AND METHODS OF ENRICHING HEMATOPOIETIC STEM CELL POPULATIONS AND METHODS OF USE THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2023-02-16 | — | — | WO | disclosed |
| US-20210387953-A1 | BENZOXAZOLE AND RELATED COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2021-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240156872-A1 | Use of Chaperone-Mediated Autophagy Activators For Treating Or Preventing Blood Cancers And Myelodysplastic Syndromes And Enriching Hematopoietic Stem Cell Populations | SQSTM1, MCL1, HSPA2 | MAPT 2357/4885TP53 166/4885CASP3 1753/4885 |
| US-20210387953-A1 | BENZOXAZOLE AND RELATED COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | CLPX, SQSTM1, ATG7 | MAPT 976/4885TP53 2276/4885CASP3 2371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.