SCHEMBL23754252

SCHEMBL23754252

N#Cc1cc(C(=O)O)c(C(F)(F)F)cc1-c1ccc(C(F)(F)F)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 2/20 0.50
TAS2R14 Q9NYV8 2/20 0.46
CYP2C8 P10632 1/20 0.44
RXRA P19793 1/20 0.43
RXRB P28702 1/20 0.43
RXRG P48443 1/20 0.43
CES2 O00748 1/20 0.42
PTGDR2 Q9Y5Y4 1/20 0.42
AR P10275 3/20 0.41
PRKAB2 O43741 1/20 0.41
PRKAG1 P54619 1/20 0.41
PRKAA2 P54646 1/20 0.41
PRKAA1 Q13131 1/20 0.41
PRKAG3 Q9UGI9 1/20 0.41
PRKAG2 Q9UGJ0 1/20 0.41
PRKAB1 Q9Y478 1/20 0.41
PSEN1 P49768 1/20 0.41
PSEN2 P49810 1/20 0.41
APH1B Q8WW43 1/20 0.41
NCSTN Q92542 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31574206 1.00 XDH (0.50) XDHTAS2R14CYP2C8RXRARXRB
SCHEMBL23768294 0.85 XDH (0.55) XDHTAS2R14CYP2C8RXRARXRB
SCHEMBL23754114 0.85 CFTR (0.45) XDHCES2PTGDR2ARPRKAB2
SCHEMBL30129893 0.85 CFTR (0.45) XDHCES2PTGDR2ARPRKAB2
SCHEMBL23768095 0.82 XDH (0.49) XDHTAS2R14CYP2C8PTGDR2AR
SCHEMBL29876870 0.79 XDH (0.47) XDHTAS2R14PTGDR2ARPRKAB2
SCHEMBL23754254 0.79 XDH (0.47) XDHTAS2R14PTGDR2ARPRKAB2
SCHEMBL2038022 0.75 CYP2C8 (0.56) XDHTAS2R14CYP2C8RXRARXRB
SCHEMBL23768297 0.74 XDH (0.47) XDHRXRARXRBPTGDR2AR
SCHEMBL21980910 0.74 XDH (0.46) XDHTAS2R14KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12604895-B2 Pesticidally active cyclic amine compounds SYNGENTA CROP PROTECTION AG (CH) 2026-04-21 US disclosed
EP-4339187-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT Nippon Soda Co., Ltd. (JP) 2024-03-20 EP disclosed
US-20230146180-A1 PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-05-11 US disclosed
US-20230146180-A1 PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-05-11 US disclosed
EP-4103549-A1 PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS Syngenta Crop Protection AG (CH) 2022-12-21 EP disclosed
WO-2022239798-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 2022-11-17 WO disclosed
WO-2022239798-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 2022-11-17 WO disclosed
CN-115210218-A Pesticidally active cyclic amine compounds 先正达农作物保护股份公司 2022-10-18 CN disclosed
WO-2021215393-A1 BENZAMIDE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 (JP) 2021-10-28 WO disclosed
WO-2021160680-A1 PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-08-19 WO disclosed
WO-2021160680-A1 PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-08-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230146180-A1 PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS DDT, ACHE, PNMT XDH 1499/4885TAS2R14 3121/4885CYP2C8 266/4885
US-12604895-B2 Pesticidally active cyclic amine compounds CLIC1, TUBA3C, CYCS XDH 3302/4885TAS2R14 3993/4885CYP2C8 739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.