SCHEMBL23763557

SCHEMBL23763557

CC(C)(C)c1ccc2c(c1)nc1n2c2c3c4cc(C(C)(C)C)ccc4n4c3c(c3c5cc(C(C)(C)C)ccc5n1c32)n1c2ccc(C(C)(C)C)cc2nc14

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HTR1D P28221 1/20 0.34
HRH4 Q9H3N8 2/20 0.33
HRH3 Q9Y5N1 2/20 0.33
KCNH2 Q12809 2/20 0.32
PGR P06401 1/20 0.32
RORA P35398 1/20 0.32
RORC P51449 1/20 0.32
RORB Q92753 1/20 0.32
LRRK2 Q5S007 1/20 0.31
SCN10A Q9Y5Y9 1/20 0.31
PDE2A O00408 2/20 0.30
F2R P25116 1/20 0.30
PDE10A Q9Y233 1/20 0.30
KIF11 P52732 1/20 0.30
DHFR P00374 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23763499 0.90 ALDH1A1 (0.39) PGRRORARORCRORBPDE2A
SCHEMBL23763731 0.90 HTR1D (0.33) HTR1DKCNH2PGRRORARORC
SCHEMBL23763628 0.84 PTGER4 (0.34) KCNH2PGRRORARORCRORB
SCHEMBL23763559 0.84 PON1 (0.33)
SCHEMBL23763598 0.83 LMNA (0.34) KCNH2PGRRORARORCRORB
SCHEMBL23763423 0.81 CYP19A1 (0.34) KIF11
SCHEMBL23763732 0.80 HTR1D (0.31) HTR1D
SCHEMBL23763733 0.79 PLK4 (0.36) PGRRORARORCRORBPDE2A
SCHEMBL23763568 0.79 ALOX5AP (0.35) HTR1DKCNH2
SCHEMBL23763561 0.79 PGR (0.30) HTR1DPGRRORARORCRORB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3865486-A1 HETEROCYCLIC COMPOUND AND AN ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE HETEROCYCLIC COMPOUND IDEMITSU KOSAN CO., LTD. (JP) 2021-08-18 EP disclosed