SCHEMBL237660

SCHEMBL237660

C[C@H](N)C(=O)Oc1ccc(NC(=N)N)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 2/20 0.47
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
ALDH1A1 P00352 2/20 0.42
GAA P10253 2/20 0.42
LMNA P02545 1/20 0.42
TP53 P04637 1/20 0.42
LTA4H P09960 1/20 0.42
XIAP P98170 1/20 0.41
ELANE P08246 1/20 0.40
MAPK1 P28482 1/20 0.40
SMN1; SMN2 Q16637 4/20 0.40
RAB9A P51151 3/20 0.40
NPC1 O15118 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
HPGD P15428 1/20 0.40
CYP2C19 P33261 1/20 0.40
TAAR1 Q96RJ0 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11425856 0.81 ELANE (0.53) GLAMEN1KMT2AELANESMN1; SMN2
SCHEMBL15679080 0.81 ELANE (0.55) MEN1KMT2AALDH1A1LMNAELANE
SCHEMBL23493150 0.81 ELANE (0.55) MEN1KMT2AALDH1A1LMNAELANE
SCHEMBL4104242 0.80 MEN1 (0.55) GLAMEN1KMT2AALDH1A1GAA
Hydrochloric Acid SCHEMBL30184762 0.79 ELANE (0.53) MEN1KMT2AALDH1A1LMNAELANE
SCHEMBL10504279 0.79 RXFP1 (0.56) GLAMEN1KMT2AALDH1A1GAA
SCHEMBL10504965 0.79 TGM2 (0.60) GLAMEN1KMT2AALDH1A1GAA
SCHEMBL4806554 0.79 PRSS1 (0.52) ELANE
SCHEMBL11440483 0.77 KMT2A (0.41) GLAMEN1KMT2AALDH1A1GAA
SCHEMBL11427464 0.77 FPR2 (0.48) KMT2ALMNASMN1; SMN2RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3941526-A1 TRANSGLUTAMINASE CONJUGATION METHOD WITH A GLYCINE BASED LINKER Paul Scherrer Institut (CH) 2022-01-26 EP disclosed
EP-3755711-A1 IMMUNOTHERAPEUTIC COMPOSITION FOR THE TREATMENT OF CANCER Technion Research & Development Foundation Limited (IL) 2020-12-30 EP disclosed
US-20200385441-A1 IMMUNOTHERAPEUTIC COMPOSITION FOR THE TREATMENT OF CANCER TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2020-12-10 US disclosed
WO-2020188061-A1 TRANSGLUTAMINASE CONJUGATION METHOD WITH A GLYCINE BASED LINKER PAUL SCHERRER INSTITUT (CH) 2020-09-24 WO disclosed
WO-2019162937-A1 IMMUNOTHERAPEUTIC COMPOSITION FOR THE TREATMENT OF CANCER TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2019-08-29 WO disclosed
US-20190031759-A1 CHIMERIC ANTIGEN RECEPTORS AND METHODS OF THEIR USE TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2019-01-31 US disclosed
EP-1409547-B1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR IMMUNE DECEPTION, PARTICULARLY USEFUL IN THE TREATMENT OF CANCER TECHNION RES & DEV FOUNDATION (IL) 2017-09-20 EP disclosed
US-20170198046-A1 COMPOSITIONS CAPABLE OF SPECIFICALLY BINDING PARTICULAR HUMAN ANTIGEN PRESENTING MOLECULE/ ANTIGEN COMPLEXES AND USES THEREOF TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2017-07-13 US disclosed
WO-2016174652-A1 CHIMERIC ANTIGEN RECEPTORS AND METHODS OF THEIR USE TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2016-11-03 WO disclosed
EP-2970289-A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE Vertex Pharmaceuticals Inc. (US) 2016-01-20 EP disclosed
US-6544759-B1 Genetic engineering; isolated nucleic acid YEDA RESEARCH AND DEVELOPMENT CO. LTD (IL) 2003-04-08 US disclosed
US-20030017134-A1 Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. 2003-01-23 US disclosed
WO-2002102299-A2 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR IMMUNE DECEPTION, PARTICULARLY USEFUL IN THE TREATMENT OF CANCER TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) 2002-12-27 WO disclosed
WO-2002094981-A2 METHOD OF IDENTIFYING PEPTIDES CAPABLE OF BINDING TO MHC MOLECULES, PEPTIDES IDENTIFIED THEREBY AND THEIR USES TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) 2002-11-28 WO disclosed
US-20020115069-A1 EH DOMAIN CONTAINING GENES AND PROTEINS Ramot University Authority of Applied Research and Industrial Development Ltd. (IL) 2002-08-22 US disclosed
WO-2002055543-A2 HYBRID PEPTIDES FOR TREATMENT OF BACTEREMIA AND SEPTICEMIA UNIV RAMOT (IL) 2002-07-18 WO disclosed
WO-2001081540-A2 GROWTH FACTOR WHICH ACTS THROUGH ERB B-4 RTK YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2001-11-01 WO disclosed
EP-1100901-A1 TUMOR ASSOCIATED ANTIGEN PEPTIDES AND USE OF SAME AS ANTI-TUMOR VACCINES YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) 2001-05-23 EP disclosed
WO-2000066707-A2 NOVEL THIAMINE TRANSPORTER, A POLYNUCLEOTIDE ENCODING SAME AND THEIR USES TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) 2000-11-09 WO disclosed
WO-2000006723-A1 TUMOR ASSOCIATED ANTIGEN PEPTIDES AND USE OF SAME AS ANTI-TUMOR VACCINES YEDA RESEARCH AND DEVELOPMENT COMPANY LTD AT THE WEIZMANN INSTITUTE OF SCIENCE (IL) 2000-02-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115069-A1 EH DOMAIN CONTAINING GENES AND PROTEINS EPS15, EHD1, PITHD1 GLA 4831/4885MEN1 1614/4885KMT2A 2620/4885
US-20170198046-A1 COMPOSITIONS CAPABLE OF SPECIFICALLY BINDING PARTICULAR HUMAN ANTIGEN PRESENTING MOLECULE/ ANTIGEN COMPLEXES AND USES THEREOF CD74, CD14, MICA GLA 1732/4885MEN1 1295/4885KMT2A 3470/4885
US-20200385441-A1 IMMUNOTHERAPEUTIC COMPOSITION FOR THE TREATMENT OF CANCER CD74, MICA, HLA-C GLA 3701/4885MEN1 3608/4885KMT2A 2977/4885
US-20030017134-A1 Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer GZMB, CD74, HLA-DRB1 GLA 2977/4885MEN1 3558/4885KMT2A 3720/4885
US-20190031759-A1 CHIMERIC ANTIGEN RECEPTORS AND METHODS OF THEIR USE HAVCR2, CD2BP2, CD74 GLA 2685/4885MEN1 4333/4885KMT2A 2822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.