Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 4/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 2/20 | 0.39 |
| ▸ | SKP1 | P63208 | 2/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770751 | 0.91 | GPR119 (0.40) | SUV39H2CKS1BSKP1SKP2MEN1 | |
| SCHEMBL29464405 | 0.84 | BRD4 (0.41) | SUV39H2CCNT1CKS1BSKP1SKP2 | |
| SCHEMBL19925051 | 0.84 | BRD4 (0.41) | SUV39H2CCNT1CKS1BSKP1SKP2 | |
| SCHEMBL23770808 | 0.83 | HTR3E (0.38) | CCNT1CDK9 | |
| SCHEMBL23770697 | 0.81 | CKS1B (0.41) | CKS1BSKP1SKP2KIF18ACCNK | |
| SCHEMBL23770508 | 0.81 | ABL1 (0.35) | MEN1KMT2ARETSMO | |
| SCHEMBL23770741 | 0.81 | ABL1 (0.35) | CCNT1CDK9SMO | |
| SCHEMBL23770855 | 0.80 | ABL1 (0.32) | SMO | |
| SCHEMBL23770831 | 0.79 | ABL1 (0.33) | — | |
| SCHEMBL23770466 | 0.76 | CYP1A2 (0.37) | CCNA2CDK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |