Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.35 |
| ▸ | RET | P07949 | 3/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770864 | 0.90 | HDAC3 (0.34) | RETP2RY1CNR1OPRM1SMO | |
| SCHEMBL23770853 | 0.90 | ABL1 (0.34) | ABL1RETOPRM1PTPN11JAK2 | |
| SCHEMBL23770789 | 0.88 | HDAC3 (0.33) | CNR1OPRM1CTSAHDAC3HDAC4 | |
| SCHEMBL23770829 | 0.87 | HDAC3 (0.33) | RETP2RY1CNR1OPRM1SMO | |
| SCHEMBL23770855 | 0.85 | ABL1 (0.32) | ABL1SMOPTPN11 | |
| SCHEMBL19925055 | 0.85 | ABL1 (0.33) | ABL1DGAT2P2RY1CNR1OPRM1 | |
| SCHEMBL23770868 | 0.82 | PTPN11 (0.37) | ABL1RETCNR1PTPN11MEN1 | |
| SCHEMBL23770446 | 0.81 | SUV39H2 (0.39) | RETSMOMEN1KMT2A | |
| SCHEMBL23770808 | 0.81 | HTR3E (0.38) | ABL1PTPN11 | |
| SCHEMBL23770757 | 0.81 | MEN1 (0.33) | OPRM1PTPN11JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |