Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770669 | 0.90 | HTR3A (0.40) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770862 | 0.88 | HTR3E (0.42) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770770 | 0.88 | ADRB2 (0.38) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770741 | 0.86 | ABL1 (0.35) | ABL1CCNT1CDK9SCN9A | |
| SCHEMBL23770731 | 0.85 | HTR3A (0.40) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770855 | 0.85 | ABL1 (0.32) | ABL1PTPN11 | |
| SCHEMBL23770831 | 0.84 | ABL1 (0.33) | ABL1 | |
| SCHEMBL23770450 | 0.84 | HTR3E (0.43) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770587 | 0.84 | ABL1 (0.39) | ABL1HTR2CCCNT1CDK9KCNH2 | |
| SCHEMBL23770819 | 0.83 | HTR3A (0.41) | HTR3EHTR3BALDH1A1HTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |