Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770454 | 0.90 | PIM1 (0.34) | ABL1HTR2CWDR5 | |
| SCHEMBL23770589 | 0.89 | WDR5 (0.31) | WDR5 | |
| SCHEMBL23770705 | 0.88 | HRH3 (0.35) | WDR5 | |
| SCHEMBL23770744 | 0.87 | RAF1 (0.33) | ABL1SOS1WDR5RAF1BRAF | |
| SCHEMBL23770795 | 0.85 | ABL1 (0.34) | ABL1WDR5RAF1BRAF | |
| SCHEMBL23770679 | 0.84 | TTR (0.32) | ABL1WDR5 | |
| SCHEMBL23770598 | 0.83 | ADRB2 (0.43) | ADRB2CYP1A2CYP2C9CYP2C19HTR2C | |
| SCHEMBL23770622 | 0.83 | CTSL (0.36) | ADRB2SOS1HTR2CRAF1BRAF | |
| SCHEMBL23770787 | 0.82 | PDE10A (0.35) | CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL23770770 | 0.81 | ADRB2 (0.38) | ADRB2CYP1A2ABL1CYP2C9SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |