Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.32 |
| ▸ | RBP4 | P02753 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770744 | 0.85 | RAF1 (0.33) | RBP4ABL1WDR5 | |
| SCHEMBL23770454 | 0.85 | PIM1 (0.34) | ABL1WDR5 | |
| SCHEMBL23770705 | 0.85 | HRH3 (0.35) | WDR5 | |
| SCHEMBL23770643 | 0.84 | ADRB2 (0.37) | ABL1WDR5 | |
| SCHEMBL23770589 | 0.83 | WDR5 (0.31) | WDR5 | |
| SCHEMBL23770795 | 0.81 | ABL1 (0.34) | ABL1WDR5 | |
| SCHEMBL23770889 | 0.79 | WDR5 (0.31) | TTRABL1WDR5 | |
| SCHEMBL23770649 | 0.79 | PIM1 (0.34) | TTRCTSS | |
| SCHEMBL23770830 | 0.79 | MAP4K1 (0.33) | WDR5 | |
| SCHEMBL23770787 | 0.76 | PDE10A (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |