Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | WDR5 | P61964 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.30 |
| ▸ | SCD | O00767 | 1/20 | 0.30 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770589 | 0.89 | WDR5 (0.31) | WDR5 | |
| SCHEMBL23770643 | 0.88 | ADRB2 (0.37) | WDR5 | |
| SCHEMBL23770559 | 0.87 | HRH3 (0.34) | HRH3KIF18A | |
| SCHEMBL23770744 | 0.86 | RAF1 (0.33) | WDR5 | |
| SCHEMBL23770679 | 0.85 | TTR (0.32) | WDR5 | |
| SCHEMBL23770795 | 0.85 | ABL1 (0.34) | WDR5 | |
| SCHEMBL23770454 | 0.84 | PIM1 (0.34) | WDR5ACVR1 | |
| SCHEMBL19925077 | 0.81 | SCN1A (0.36) | HRH3WDR5 | |
| SCHEMBL29464443 | 0.81 | SCN1A (0.36) | HRH3WDR5 | |
| SCHEMBL23770830 | 0.80 | MAP4K1 (0.33) | WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |