Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770559 | 0.88 | HRH3 (0.34) | HRH3KIF18A | |
| SCHEMBL23770449 | 0.87 | NPC1 (0.33) | NPC1 | |
| SCHEMBL19925110 | 0.80 | GHSR (0.34) | HRH3LRRK2ADRA1DADRA1AADRA1B | |
| SCHEMBL23770705 | 0.76 | HRH3 (0.35) | HRH3KIF18ACTSC | |
| SCHEMBL23770441 | 0.74 | HTR3E (0.43) | — | |
| SCHEMBL23770451 | 0.72 | ABL1 (0.31) | ABL1 | |
| SCHEMBL23770622 | 0.70 | CTSL (0.36) | CTSC | |
| SCHEMBL23770818 | 0.69 | — | — | |
| SCHEMBL29464452 | 0.68 | SCN1A (0.35) | HRH3LRRK2KIF18A | |
| SCHEMBL19925063 | 0.68 | SCN1A (0.35) | HRH3LRRK2KIF18A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |