Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 16/20 | 0.42 |
| ▸ | ATRIP | Q8WXE1 | 16/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770615 | 0.89 | ATR (0.43) | ATRATRIPRAF1BRAF | |
| SCHEMBL29464489 | 0.84 | ATR (0.42) | ATRATRIPPIK3CAMTORCHEK1 | |
| SCHEMBL19951355 | 0.84 | ATR (0.42) | ATRATRIPPIK3CAMTORCHEK1 | |
| SCHEMBL19951353 | 0.84 | ATR (0.42) | ATRATRIPPIK3CAMTORCHEK1 | |
| SCHEMBL23770596 | 0.80 | ADRB1 (0.41) | RAF1BRAF | |
| SCHEMBL23770583 | 0.80 | RAF1 (0.36) | RAF1BRAF | |
| SCHEMBL23770447 | 0.78 | SOS1 (0.34) | RAF1BRAF | |
| SCHEMBL23770773 | 0.78 | ABL1 (0.37) | — | |
| SCHEMBL23770699 | 0.76 | ATR (0.45) | ATRATRIPPIK3CAMTORPDCD1 | |
| SCHEMBL23770607 | 0.74 | JAK2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |