Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.32 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.32 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | PRKCA | P17252 | 2/20 | 0.30 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770841 | 0.92 | MEN1 (0.34) | MEN1KMT2ALMNARAB9AOPRM1 | |
| SCHEMBL23770853 | 0.91 | ABL1 (0.34) | MEN1KMT2ALMNARAB9AOPRM1 | |
| SCHEMBL23770864 | 0.88 | HDAC3 (0.34) | MEN1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL23770832 | 0.87 | RBP4 (0.33) | PRKCAPRKCQPTPN11 | |
| SCHEMBL19925244 | 0.84 | SCN9A (0.33) | MEN1KMT2ALMNARAB9ATACR1 | |
| SCHEMBL29464451 | 0.84 | SCN9A (0.33) | MEN1KMT2ALMNARAB9ATACR1 | |
| SCHEMBL23770497 | 0.83 | RBP4 (0.35) | PRKCAPRKCQ | |
| SCHEMBL23770433 | 0.83 | PDE10A (0.36) | MEN1KMT2ATACR1GAAL3MBTL1 | |
| SCHEMBL23770865 | 0.82 | KHK (0.35) | MEN1KMT2ATACR1PTPN11 | |
| SCHEMBL23770723 | 0.82 | PTPN11 (0.35) | LMNATACR1POLBGAAPTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |