Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 4/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | RBP4 | P02753 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770757 | 0.91 | MEN1 (0.33) | PTPN11LMNARAB9AOPRM1MEN1 | |
| SCHEMBL23770445 | 0.90 | WDR5 (0.31) | ABL1RETLMNARAB9AWDR5 | |
| SCHEMBL23770508 | 0.90 | ABL1 (0.35) | ABL1RETPTPN11OPRM1MEN1 | |
| SCHEMBL23770841 | 0.88 | MEN1 (0.34) | PTPN11LMNARAB9AOPRM1MEN1 | |
| SCHEMBL19925765 | 0.85 | WDR5 (0.33) | ABL1RETPTPN11WDR5OPRM1 | |
| SCHEMBL23770463 | 0.83 | BTK (0.34) | ABL1RBP4TTR | |
| SCHEMBL23770452 | 0.83 | PDE10A (0.34) | ABL1 | |
| SCHEMBL19970118 | 0.82 | RORC (0.35) | PTPN11LMNA | |
| SCHEMBL23770466 | 0.82 | CYP1A2 (0.37) | ABL1WDR5 | |
| SCHEMBL23770770 | 0.82 | ADRB2 (0.38) | ABL1WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |