Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770724 | 0.90 | MAP4K1 (0.34) | MAP4K1CCNT1 | |
| SCHEMBL23770822 | 0.89 | MPL (0.33) | HSD11B1CNR2MPLKRASGRIN2B | |
| SCHEMBL23770632 | 0.86 | ADRB2 (0.42) | HSD11B1CNR2CNR1KRASCCNT1 | |
| SCHEMBL23770574 | 0.84 | CCNT1 (0.31) | MAP4K1CCNT1 | |
| SCHEMBL23770836 | 0.82 | MPL (0.33) | MPLCLK2LRRK2 | |
| SCHEMBL23770651 | 0.82 | RORC (0.38) | HSD11B1CNR2CNR1KRASRORC | |
| SCHEMBL23770753 | 0.82 | GRIN2B (0.36) | MPLGRIN2BCLK2LRRK2 | |
| SCHEMBL23770810 | 0.81 | MPL (0.32) | MPLGRIN2BCCNT1 | |
| SCHEMBL29464376 | 0.81 | GHSR (0.36) | HSD11B1MPLTRPV1MAP4K1KRAS | |
| SCHEMBL19968851 | 0.81 | GHSR (0.36) | HSD11B1MPLTRPV1MAP4K1KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |