Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 7/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770470 | 0.93 | DGAT1 (0.35) | DGAT1KCNH2RBP4CNR1BTK | |
| SCHEMBL23770877 | 0.92 | RBP4 (0.35) | DGAT1KCNH2RBP4CNR1HTR2A | |
| SCHEMBL19970086 | 0.91 | DGAT1 (0.37) | DGAT1KCNH2RBP4CNR1BTK | |
| SCHEMBL19970017 | 0.88 | HCRTR1 (0.35) | DGAT1KCNH2CNR1BTKHCRTR1 | |
| SCHEMBL23770734 | 0.88 | HCRTR1 (0.35) | DGAT1KCNH2CNR1BTKHCRTR1 | |
| SCHEMBL19970083 | 0.86 | BTK (0.34) | DGAT1KCNH2BTKHCRTR1HCRTR2 | |
| SCHEMBL23770875 | 0.86 | BTK (0.34) | DGAT1KCNH2BTKHCRTR1HCRTR2 | |
| SCHEMBL19951333 | 0.86 | RBP4 (0.36) | DGAT1KCNH2RBP4CNR1HTR2A | |
| SCHEMBL19927799 | 0.86 | RBP4 (0.36) | DGAT1KCNH2RBP4CNR1HTR2A | |
| SCHEMBL23770722 | 0.84 | HMOX1 (0.34) | DGAT1KCNH2CNR1CNR2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |