Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 7/20 | 0.33 |
| ▸ | JAK1 | P23458 | 7/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TPH1 | P17752 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770877 | 0.92 | RBP4 (0.35) | RORCDGAT1KCNH2CNR1CNR2 | |
| SCHEMBL23770470 | 0.92 | DGAT1 (0.35) | HMOX1JAK2JAK1TRPV1P2RX3 | |
| SCHEMBL19970118 | 0.89 | RORC (0.35) | RORCDGAT1KCNH2TPH1CNR1 | |
| SCHEMBL19951362 | 0.85 | RORC (0.34) | HMOX1JAK2JAK1RORCTRPV1 | |
| SCHEMBL23770834 | 0.84 | DGAT1 (0.36) | DGAT1KCNH2CNR1CNR2BRAF | |
| SCHEMBL23770654 | 0.84 | RORC (0.40) | RORCTRPV1CNR1BRAF | |
| SCHEMBL23770651 | 0.83 | RORC (0.38) | RORCDGAT1KCNH2CNR1CNR2 | |
| SCHEMBL23770880 | 0.82 | RORC (0.41) | RORCBRAF | |
| SCHEMBL19970086 | 0.80 | DGAT1 (0.37) | RORCDGAT1KCNH2CNR1CNR2 | |
| SCHEMBL23770892 | 0.80 | RORC (0.35) | RORCBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |