Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 7/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770722 | 0.92 | HMOX1 (0.34) | CNR1BRAFRORCMCHR1DGAT1 | |
| SCHEMBL23770834 | 0.92 | DGAT1 (0.36) | RBP4CNR1HTR2AHTR2CRAF1 | |
| SCHEMBL19970118 | 0.90 | RORC (0.35) | CNR1RAF1BRAFRORCTP53 | |
| SCHEMBL23770654 | 0.86 | RORC (0.40) | CNR1ALDH1A1BRAFRORCMAPT | |
| SCHEMBL19951381 | 0.85 | RBP4 (0.36) | RBP4CNR1HTR2AHTR2CALDH1A1 | |
| SCHEMBL23770651 | 0.84 | RORC (0.38) | CNR1BRAFRORCDGAT1KCNH2 | |
| SCHEMBL23770880 | 0.84 | RORC (0.41) | BRAFRORCBTK | |
| SCHEMBL23770470 | 0.84 | DGAT1 (0.35) | RBP4CNR1DGAT1KCNH2CNR2 | |
| SCHEMBL19970086 | 0.82 | DGAT1 (0.37) | RBP4CNR1RAF1BRAFRORC | |
| SCHEMBL23770892 | 0.81 | RORC (0.35) | BRAFRORCBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |