Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 3/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29464441 | 0.81 | KIF18A (0.35) | DGAT1KCNH2CNR1MEN1POLB | |
| SCHEMBL19951369 | 0.81 | KIF18A (0.35) | DGAT1KCNH2CNR1MEN1POLB | |
| SCHEMBL19951367 | 0.81 | KIF18A (0.35) | DGAT1KCNH2CNR1MEN1POLB | |
| SCHEMBL23770638 | 0.78 | EIF2AK4 (0.31) | — | |
| SCHEMBL23770748 | 0.76 | RORC (0.33) | — | |
| SCHEMBL23770750 | 0.71 | DGAT1 (0.32) | DGAT1KCNH2CNR1KIF18ACYP1A2 | |
| SCHEMBL19925398 | 0.70 | KIF18A (0.33) | DGAT1KCNH2KIF18ACYP1A2CYP2D6 | |
| SCHEMBL29464342 | 0.70 | KIF18A (0.33) | DGAT1KCNH2KIF18ACYP1A2CYP2D6 | |
| SCHEMBL19925396 | 0.70 | KIF18A (0.33) | DGAT1KCNH2KIF18ACYP1A2CYP2D6 | |
| SCHEMBL19927751 | 0.70 | CHRNA7 (0.37) | DGAT1KCNH2CNR1SYKKIF18A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |