Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20148901 | 0.85 | MAPT (0.38) | HPGDLMNAALDH1A1MAPTTDP1 | |
| SCHEMBL28474445 | 0.83 | LMNA (0.38) | HPGDLMNATP53CYP3A4ALOX15 | |
| SCHEMBL11441072 | 0.83 | HPGD (0.41) | HPGDLMNATP53CYP3A4ALOX15 | |
| SCHEMBL1567262 | 0.78 | ALOX15 (0.41) | HPGDLMNATP53CYP3A4ALOX15 | |
| SCHEMBL24499547 | 0.78 | ALOX5AP (0.49) | HPGDLMNATP53CYP3A4ALOX15 | |
| SCHEMBL2308071 | 0.78 | LMNA (0.46) | HPGDLMNATP53CYP3A4ALOX15 | |
| SCHEMBL7585737 | 0.78 | LMNA (0.37) | HPGDLMNATP53CYP3A4ALOX15 | |
| SCHEMBL23771981 | 0.78 | ALOX5AP (0.39) | ALDH1A1TDP1PTGS2ALOX5APFEN1 | |
| SCHEMBL2955217 | 0.74 | CA2 (0.43) | HPGDLMNATP53CYP3A4ALOX15 | |
| SCHEMBL1480589 | 0.74 | KDM4E (0.39) | HPGDALDH1A1MAPTTDP1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11814392-B2 | Chromenopyridine-based compounds and methods of making and use thereof | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2023-11-14 | — | — | US | disclosed |
| US-11814392-B2 | Chromenopyridine-based compounds and methods of making and use thereof | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2023-11-14 | — | — | US | disclosed |
| US-20220135581-A1 | CHROMENOPYRIDINE-BASED COMPOUNDS AND METHODS OF MAKING AND USE THEREOF | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE | 2022-05-05 | — | — | US | disclosed |
| US-20210251991-A1 | SUBSTITUTED 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210251991-A1 | SUBSTITUTED 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | HAVCR2, CDV3, HMBS | HPGD 981/4885LMNA 2022/4885TP53 195/4885 |
| US-20220135581-A1 | CHROMENOPYRIDINE-BASED COMPOUNDS AND METHODS OF MAKING AND USE THEREOF | DPYD, DCK, TYMP | HPGD 451/4885LMNA 2546/4885TP53 29/4885 |
| US-11814392-B2 | Chromenopyridine-based compounds and methods of making and use thereof | DPYD, DCK, TYMP | HPGD 451/4885LMNA 2546/4885TP53 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.