SCHEMBL237754

SCHEMBL237754

COC(C)(C)[C@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)nc32)[C@H](O)[C@@H]1O

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ HINT1 P49773 6/20 0.58
▸ NT5E P21589 1/20 0.55
▸ STING1 Q86WV6 2/20 0.52
▸ PDE3B Q13370 1/20 0.52
▸ PDE3A Q14432 1/20 0.52
▸ GSK3A P49840 2/20 0.52
▸ RPS6KA3 P51812 2/20 0.52
▸ MAPK14 Q16539 2/20 0.52
▸ TGM2 P21980 1/20 0.51
▸ TAAR1 Q96RJ0 1/20 0.51
▸ PNP P00491 1/20 0.50
▸ KRAS P01116 1/20 0.49
▸ HPGD P15428 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1506529 0.86 NT5E (0.56) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL16555277 0.84 HINT1 (0.55) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL16496063 0.83 TGM2 (0.54) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL1120568 0.82 HINT1 (0.59) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL20870831 0.82 HPGD (0.60) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL24299397 0.82 HINT1 (0.62) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL13833323 0.82 HINT1 (0.62) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL16114092 0.82 HINT1 (0.62) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL4278130 0.82 HINT1 (0.62) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL2510562 0.82 HINT1 (0.62) HINT1NT5ESTING1PDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 284 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025038853-A1 USHER SYNDROME-RELATED GENE MODIFICATION AMBER BIO INC. (US) 2025-02-20 — — WO claimed
EP-4379052-A2 MRNA PURIFICATION BY TANGENTIAL FLOW FILTRATION Ethris GmbH (DE) 2024-06-05 — — EP claimed
EP-4306643-A2 PLASMID CONTAINING A SEQUENCE ENCODING AN MRNA WITH A SEGMENTED POLY(A) TAIL ethris GmbH (DE) 2024-01-17 — — EP claimed
EP-1027432-A2 RIBOZYMES TARGETED TO IL-15 mRNA Hisamitsu Pharmaceutical Co., Inc. (JP) 2000-08-16 — — EP claimed
US-6087172-A FOR TREATMENT OF RHEUMATOID ARTHRITIS BY SUPPRESSION OF INTERLEUKIN-15 PRODUCTION HISAMITSU PHARMACEUTICAL CO., INC. (JP) 2000-07-11 — — US claimed
EP-0948513-A1 DELIVERY CONSTRUCT FOR ANTISENSE NUCLEIC ACIDS AND METHODS OF USE THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) 1999-10-13 — — EP claimed
US-5942395-A A RECOMBINANT RNA HAVING A HAMMERHEAD OR HAIRPIN RIBOZYME CATALYTIC SEQUENCE AND A SMALL NUCLEOLAR RNA STABILIZING MOTIF; ANTICARCINOGENIC/ANTITUMOR/ANTIPROTOZOA AGENTS, TREATMENT OF HIV, AUTOIMMUNE AND CARDIOVASCULAR DISEASES UNIVERSITE DE MONTREAL (CA) 1999-08-24 — — US claimed
WO-1999023208-A2 RIBOZYMES TARGETED TO IL-15 mRNA HISAMITSU PHARMACEUTICAL CO., INC. (JP) 1999-05-14 — — WO claimed
WO-1998050408-A1 HYBRID RIBOZYMES AND METHODS OF USE UNIVERSITY OF MASSACHUSETTS (US) 1998-11-12 — — WO claimed
US-5814500-A FOR SUPPRESSING EXPRESSION OF A TARGET GENE THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) 1998-09-29 — — US claimed
WO-1998018811-A1 DELIVERY CONSTRUCT FOR ANTISENSE NUCLEIC ACIDS AND METHODS OF USE THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) 1998-05-07 — — WO claimed
CN-113396219-B Purification of mRNA by tangential flow filtration ETHRIS GMBH (DE) 2026-05-26 — — CN disclosed
EP-4717779-A2 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TriLink BioTechnologies, LLC (US) 2026-04-01 — — EP disclosed
EP-4276189-B1 INITIATING CAPPED OLIGONUCLEOTIDE PRIMERS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES LLC (US) 2026-04-01 — — EP disclosed
CN-121586722-A Compositions and methods for generating immunity to bacterial infections 辛泰伦有限责任公司 2026-02-27 — — CN disclosed
WO-1998045450-A1 PURIFIED TELOMERASE GERON CORPORATION (US) 1998-10-15 — — WO disclosed
US-5814500-A FOR SUPPRESSING EXPRESSION OF A TARGET GENE THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) 1998-09-29 — — US disclosed
WO-1998039661-A1 METHOD FOR IDENTIFYING HORMONALLY MODULATED GENES DIAGNOSTIC PRODUCTS CORPORATION (US) 1998-09-11 — — WO disclosed
WO-1998018811-A1 DELIVERY CONSTRUCT FOR ANTISENSE NUCLEIC ACIDS AND METHODS OF USE THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) 1998-05-07 — — WO disclosed
EP-0311694-A1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION RIKAGAKU KENKYUSHO (JP) 1989-04-19 — — EP disclosed
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