Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24907175 | 0.90 | NAMPT (0.45) | CNR1CNR2KDM4CKDM4APHF8 | |
| SCHEMBL28340875 | 0.90 | NAMPT (0.45) | CNR1CNR2KDM4CKDM4APHF8 | |
| SCHEMBL24193602 | 0.89 | CNR1 (0.43) | CNR1CNR2LMNAPKMFAAH | |
| SCHEMBL24490138 | 0.87 | LMNA (0.50) | CNR1CNR2LMNAPKMFAAH | |
| SCHEMBL20287600 | 0.86 | ALDH1A1 (0.52) | CNR1CNR2LMNAPKMALDH1A1 | |
| SCHEMBL425951 | 0.86 | ALDH1A1 (0.55) | CNR1CNR2KDM4CKDM4APHF8 | |
| SCHEMBL24950257 | 0.85 | LMNA (0.51) | CNR1CNR2LMNAPKMFAAH | |
| SCHEMBL24701333 | 0.84 | CNR1 (0.43) | CNR1CNR2KDM4CKDM4APHF8 | |
| SCHEMBL23790088 | 0.84 | FAAH (0.47) | FAAHALDH1A1TSHRSIGMAR1DNM1 | |
| SCHEMBL24818366 | 0.84 | NAMPT (0.52) | CNR1CNR2KDM4CKDM4APHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220401564-A1 | SELECTIVE HISTONE DEACETYLASE (HDAC) DEGRADERS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-12-22 | — | — | US | disclosed |
| US-20210276996-A1 | DEGRADERS THAT TARGET PROTEINS VIA KEAP1 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220401564-A1 | SELECTIVE HISTONE DEACETYLASE (HDAC) DEGRADERS AND METHODS OF USE THEREOF | HDAC3, HDAC1, HDAC2 | CNR1 2497/4885CNR2 3097/4885KDM4C 66/4885 |
| US-20210276996-A1 | DEGRADERS THAT TARGET PROTEINS VIA KEAP1 | KEAP1, CUL3, CUL2 | CNR1 4416/4885CNR2 4715/4885KDM4C 2498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.