SCHEMBL238048

SCHEMBL238048

CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 1.00
KMT2A Q03164 1/20 1.00
PTGER4 P35408 1/20 0.82
PTGER3 P43115 1/20 0.82
AGTR1 P30556 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29409702 1.00 MEN1 (1.00) MEN1KMT2APTGER4PTGER3AGTR1
SCHEMBL5213348 0.93 MEN1 (0.88) MEN1KMT2APTGER4PTGER3AGTR1
SCHEMBL3490486 0.93 MEN1 (0.86) MEN1KMT2APTGER4PTGER3AGTR1
Potassium SCHEMBL3490489 0.93 MEN1 (0.86) MEN1KMT2APTGER4PTGER3AGTR1
SCHEMBL3489772 0.90 PTGER4 (1.00) MEN1KMT2APTGER4PTGER3AGTR1
SCHEMBL9565889 0.89 AGTR1 (0.83) AGTR1
L-159913 SCHEMBL9144158 0.88 AGTR1 (1.00) AGTR1
SCHEMBL9565941 0.88 AGTR1 (0.86) PTGER4PTGER3AGTR1
SCHEMBL29433721 0.88 PTGER4 (0.82) MEN1KMT2APTGER4PTGER3AGTR1
SCHEMBL9566072 0.88 PTGER4 (0.82) MEN1KMT2APTGER4PTGER3AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240342196-A1 TARGETING SELECT LIPID SIGNALING TO COUNTER TYPE 1 DIABETES (T1D) UAB RES FOUND (US) 2024-10-17 US claimed
EP-2362733-B1 MATERIALS AND METHODS TO ENHANCE HEMATOPOIETIC STEM CELLS ENGRAFTMENT PROCEDURES UNIV INDIANA RES & TECH CORP (US) 2017-04-12 EP claimed
US-20160030478-A1 MATERIALS AND METHODS TO ENHANCE HEMATOPOIETIC STEM CELLS ENGRAFTMENT PROCEDURES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION 2016-02-04 US claimed
EP-2555774-B1 Medicine combinations containing pde4 inhibitors and ep4 receptor antagonists BOEHRINGER INGELHEIM INT (DE) 2015-10-21 EP claimed
US-20140377214-A1 MATERIALS AND METHODS TO ENHANCE HEMATOPOIETIC STEM CELLS ENGRAFTMENT PROCEDURES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION 2014-12-25 US claimed
US-8877758-B2 Combinations of medicaments, containing PDE4-inhibitors and EP4-receptor-antagonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-11-04 US claimed
US-20140065706-A1 MATERIALS AND METHODS FOR MOBILIZING CELLS INCLUDING CD34+, HEMATOPOIETIC COLONY FORMING, AND ENDOTHELIAL COLONY FORMING CELLS INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORP. (US) 2014-03-06 US claimed
US-20140017339-A1 MATERIALS AND METHODS FOR TREATING RADIATION POISONING INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORP. (US) 2014-01-16 US claimed
US-20130237527-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-09-12 US claimed
US-20130225609-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-08-29 US claimed
US-20030100591-A1 Methods of treatment of uterine pathological conditions MEDICAL RESEARCH COUNCIL (GB) 2003-05-29 US claimed
WO-2003030911-A1 USE OF PROSTAGLANDIN E SYNTHASE INHIBITORS, OR EP2 OR EP4 RECEPTOR ANTAGONISTS, IN THE TREATMENT OF A PATHOLOGICAL CONDITION OF THE UTERUS MEDICAL RESEARCH COUNCIL (GB) 2003-04-17 WO claimed
EP-1148877-A4 METHODS FOR INHIBITING BONE RESORPTION MERCK & CO INC (US) 2003-01-22 EP claimed
JP-2002527393-A 2002-08-27 JP claimed
US-6414006-B1 ADMINISTERING A PROSTAGLANDIN RECEPTOR EP4 SUBTYPE ANTAGONIST; TREATING BONE DISORDERS SUCH AS OSTEOPOROSIS AND PAGET'S DISEASE; WORKS BY INHIBITING THE BONE RESORPTION OF THE OSTEOCLASTS MERCK FROSST CANADA & CO. (CA) 2002-07-02 US claimed
US-20020082287-A1 METHODS FOR INHIBITING BONE RESORPTION MERCK FROSST CANADA LTD. (CA) 2002-06-27 US claimed
EP-1148877-A1 METHODS FOR INHIBITING BONE RESORPTION Merck & Co., Inc. (US) 2001-10-31 EP claimed
US-20010018433-A1 Administering a bisphosphonate compound; prostaglandin antagonist MERCK & CO., INC. 2001-08-30 US claimed
US-20010012838-A1 Methods for inhibiting bone resorption MERCK & CO., INC. 2001-08-09 US claimed
WO-2000021532-A1 METHODS FOR INHIBITING BONE RESORPTION MERCK & CO., INC. (US) 2000-04-20 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020082287-A1 METHODS FOR INHIBITING BONE RESORPTION PTGER4, PTGER1, PTGER3 MEN1 3372/4885KMT2A 2422/4885PTGER4 1/4885
US-20130225609-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS PTGER4, PTGER1, PDE4A MEN1 4030/4885KMT2A 3334/4885PTGER4 1/4885
US-20010018433-A1 Administering a bisphosphonate compound; prostaglandin antagonist PTGER4, PTGER1, PTGER2 MEN1 2541/4885KMT2A 3695/4885PTGER4 1/4885
US-20240342196-A1 TARGETING SELECT LIPID SIGNALING TO COUNTER TYPE 1 DIABETES (T1D) DGKB, PLIN1, SPTLC1 MEN1 4030/4885KMT2A 3644/4885PTGER4 3285/4885
US-20130237527-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS PTGER4, PTGER1, PTGER3 MEN1 3955/4885KMT2A 2847/4885PTGER4 1/4885
US-20010012838-A1 Methods for inhibiting bone resorption PTGER4, PTGER1, PTGER3 MEN1 3372/4885KMT2A 2422/4885PTGER4 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.