Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.62 |
| ▸ | GAA | P10253 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10942888 | 0.82 | CYP3A4 (0.68) | CYP3A4ALOX5TSHRPTGS2GAA | |
| SCHEMBL9461862 | 0.82 | PTGS2 (0.67) | CYP3A4PTGS2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL28045428 | 0.82 | PTGS2 (0.67) | CYP3A4PTGS2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL15541389 | 0.80 | PTGS2 (0.64) | CYP3A4PTGS2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL8743016 | 0.80 | KMT2A (0.68) | CYP3A4ALOX5TSHRGAAALDH1A1 | |
| SCHEMBL424604 | 0.80 | CYP3A4 (0.65) | CYP3A4ALOX5TSHRPTGS2GAA | |
| SCHEMBL6599028 | 0.79 | CYP3A4 (0.59) | CYP3A4ALOX5TSHRGAAALDH1A1 | |
| SCHEMBL2237027 | 0.79 | PTGS2 (0.58) | CYP3A4PTGS2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL8602491 | 0.78 | NPC1 (0.63) | CYP3A4PTGS2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL425708 | 0.78 | GAA (0.63) | CYP3A4ALOX5TSHRGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894326-B | 2, 3-Hydrogen substituted aminoindole derivative, preparation method and application thereof | 佛山大学 | 2025-02-11 | — | — | CN | disclosed |
| CN-115894326-A | 2,3-hydrogen substituted aminoindole derivative, preparation method and application thereof | 佛山科学技术学院 | 2023-04-04 | — | — | CN | disclosed |
| CN-109467528-B | Synthesis method of 1-aminoindole derivative | 佛山科学技术学院 | 2020-11-06 | — | — | CN | disclosed |
| WO-2016092559-A1 | SUBSTITUTED PYRAZOLE DERIVATIVES HAVING ACTIVITY AS FUNGICIDES | OAT & IIL INDIA LABORATORIES PRIVATE LIMITED (IN) | 2016-06-16 | — | — | WO | disclosed |
| CN-104945403-A | Tetrahydrobenzo [ e ] [1,2,4] triaza compounds and preparation method thereof | UNIV DALIAN TECH | 2015-09-30 | — | — | CN | disclosed |
| US-8012991-B2 | 3-(2,4-dimethoxyphenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indole-6-carboxylic acid; gamma-aminobutyric acid modulator; anticarcinogenic, antitumor, antiproliferative agent; amidating a 2-aminoindole with an alpha-substituted-beta-hydroxy-alkyl acrylate | SANOFI-AVENTIS (FR) | 2011-09-06 | — | — | US | disclosed |
| US-20080214538-A1 | Pyridoindolone Derivatives Substituted in the 3-Position by a Phenyl, Their Preparation and Their Application in Therapeutics | SANOFI-AVENTIS (FR) | 2008-09-04 | — | — | US | disclosed |
| US-7390818-B2 | Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-06-24 | — | — | US | disclosed |
| EP-1556382-B1 | 3-PHENYL SUBSTITUTED PYRIDOINDOLONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2008-05-28 | — | — | EP | disclosed |
| US-20050288318-A1 | Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2005-12-29 | — | — | US | disclosed |
| EP-1556382-A1 | 3-PHENYL SUBSTITUTED PYRIDOINDOLONE, PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041817-A1 | 3-PHENYL SUBSTITUTED PYRIDOINDOLONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288318-A1 | Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics | PNPO, PDXK, PLPBP | CYP3A4 218/4885ALOX5 353/4885TSHR 713/4885 |
| US-20080214538-A1 | Pyridoindolone Derivatives Substituted in the 3-Position by a Phenyl, Their Preparation and Their Application in Therapeutics | PNPO, PLPBP, DPYD | CYP3A4 296/4885ALOX5 517/4885TSHR 625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.