Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25522404 | 0.78 | ABL1 (0.33) | NNMT | |
| SCHEMBL3620179 | 0.77 | NOS3 (0.50) | NNMTALDH1A1KDM4EBRD4MAPT | |
| SCHEMBL23845497 | 0.75 | PDGFRB (0.37) | NNMTALDH1A1KDM4EMAPT | |
| SCHEMBL23845561 | 0.74 | NNMT (0.33) | NNMTALDH1A1 | |
| SCHEMBL4751919 | 0.72 | NNMT (0.37) | NNMTALDH1A1KDM4EBRD4MAPT | |
| SCHEMBL20772266 | 0.72 | NNMT (0.37) | NNMTALDH1A1KDM4EBRD4MAPT | |
| SCHEMBL24099889 | 0.72 | ALDH1A1 (0.42) | NNMTALDH1A1KDM4EBRD4MAPT | |
| SCHEMBL20772252 | 0.72 | NNMT (0.37) | NNMTALDH1A1KDM4EBRD4MAPT | |
| SCHEMBL30094598 | 0.69 | ALDH1A1 (0.36) | ALDH1A1GRM5MAPT | |
| SCHEMBL23833648 | 0.69 | ALDH1A1 (0.36) | ALDH1A1GRM5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188938-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE | AKEBIA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |