Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23845626 | 0.75 | NNMT (0.39) | ALDH1A1NNMTKDM4EMAPT | |
| SCHEMBL21253047 | 0.70 | NPC1 (0.42) | CYP1A2CYP2D6CYP3A4LMNACYP2C9 | |
| SCHEMBL23833599 | 0.70 | ALDH1A1 (0.48) | CYP3A4CYP2C19LMNATDP1ALDH1A1 | |
| SCHEMBL3859718 | 0.69 | HPGD (0.41) | CYP1A2CYP2D6CYP3A4CYP2C19LMNA | |
| SCHEMBL3620179 | 0.68 | NOS3 (0.50) | PDGFRBPDGFRALMNATDP1ALDH1A1 | |
| SCHEMBL810305 | 0.67 | NPC1 (0.42) | LMNAALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL23845561 | 0.66 | NNMT (0.33) | ALDH1A1NNMTNPC1RAB9A | |
| SCHEMBL23832253 | 0.66 | GABRP (0.61) | ALDH1A1KMT2ANNMTGAAKDM4E | |
| SCHEMBL20772266 | 0.64 | NNMT (0.37) | LMNATDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL20772252 | 0.64 | NNMT (0.37) | ALDH1A1CLK4NNMTJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188938-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE | AKEBIA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |