Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 1.00 |
| ▸ | CNR2 | P34972 | 2/20 | 0.66 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.65 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.65 |
| ▸ | MGAM | O43451 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23851337 | 0.92 | RORC (1.00) | RORCCNR2APOBEC3AAPOBEC3GMGAM | |
| SCHEMBL23850790 | 0.90 | RORC (1.00) | RORCCNR2APOBEC3AAPOBEC3GMGAM | |
| SCHEMBL6248317 | 0.84 | RORC (0.73) | RORCMGAMALDH1A1AMY1ATP53 | |
| SCHEMBL3801324 | 0.80 | RORC (0.68) | RORCCNR2MGAMALDH1A1AMY1A | |
| SCHEMBL6203556 | 0.79 | ALDH1A1 (0.73) | RORCCNR2APOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL23851325 | 0.79 | RORC (1.00) | RORCMGAMAMY1ATP53MAPT | |
| SCHEMBL7888385 | 0.79 | MGAM (0.73) | RORCMGAMALDH1A1GAAHPGD | |
| SCHEMBL21045596 | 0.79 | RORC (0.67) | RORCMGAMALDH1A1GAATSHR | |
| Bicarbonate SCHEMBL7890907 | 0.79 | RORC (0.67) | RORCCNR2MGAMALDH1A1AMY1A | |
| SCHEMBL3988276 | 0.78 | ALDH1A1 (0.97) | RORCCNR2ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000864-A1 | MODULATORS OF RAR-RELATED ORPHAN RECEPTORS (RORs) | 11949098 CANADA INC. (CA) | 2022-01-06 | — | — | US | claimed |
| EP-3883929-A1 | 4,5,6,7-TETRAHYDRO-L-BENZOTHIOPHENE MODULATORS OF RETINOIC ACID RECEPTOR RELATED (RAR) ORPHAN NUCLEAR RECEPTORS (RORS) | 11949098 Canada Inc. (CA) | 2021-09-29 | — | — | EP | claimed |
| CN-113166130-A | 4,5,6, 7-tetrahydro-L-benzothiophene modulators of retinoic acid receptor-associated (RAR) orphan nuclear receptors (ROR) | 11949098加拿大股份有限公司 | 2021-07-23 | — | — | CN | claimed |
| US-20220000864-A1 | MODULATORS OF RAR-RELATED ORPHAN RECEPTORS (RORs) | 11949098 CANADA INC. (CA) | 2022-01-06 | — | — | US | disclosed |
| EP-3883929-A1 | 4,5,6,7-TETRAHYDRO-L-BENZOTHIOPHENE MODULATORS OF RETINOIC ACID RECEPTOR RELATED (RAR) ORPHAN NUCLEAR RECEPTORS (RORS) | 11949098 Canada Inc. (CA) | 2021-09-29 | — | — | EP | disclosed |
| CN-113166130-A | 4,5,6, 7-tetrahydro-L-benzothiophene modulators of retinoic acid receptor-associated (RAR) orphan nuclear receptors (ROR) | 11949098加拿大股份有限公司 | 2021-07-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220000864-A1 | MODULATORS OF RAR-RELATED ORPHAN RECEPTORS (RORs) | RORB, RORC, RORA | RORC 2/4885CNR2 478/4885APOBEC3A 4300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.