Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.49 |
| ▸ | HTR2A | P28223 | 7/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867489 | 0.90 | MGLL (0.44) | SRCALDH1A1USP2LMNAPOLB | |
| SCHEMBL23867474 | 0.80 | SRC (0.51) | SRCHTR2ADRD3HTR2CALDH1A1 | |
| SCHEMBL23867478 | 0.77 | SRC (0.53) | SRCHTR2ADRD3HTR2C | |
| SCHEMBL23867532 | 0.72 | SRC (0.53) | SRCHTR2ADRD3HTR2C | |
| SCHEMBL23867534 | 0.70 | SRC (0.47) | SRCHTR2ADRD3HTR2C | |
| SCHEMBL27429703 | 0.68 | NPC1 (0.48) | SRCHTR2ADRD3HTR2CMAPT | |
| SCHEMBL27248309 | 0.66 | SRC (0.52) | SRCHTR2AHTR2CLMNA | |
| SCHEMBL3307080 | 0.66 | KMT2A (0.68) | ALDH1A1USP2LMNAPOLBMAPT | |
| SCHEMBL16897931 | 0.66 | KMT2A (0.52) | DRD3ALDH1A1LMNAPOLBMAPK1 | |
| SCHEMBL23867579 | 0.66 | SRC (0.40) | SRCALDH1A1USP2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |