Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867576 | 0.79 | LMNA (0.52) | POLBMAPTSMN1; SMN2SLC2A1L3MBTL1 | |
| SCHEMBL23867474 | 0.77 | SRC (0.51) | SRCPOLBMAPTNPC1RAB9A | |
| SCHEMBL23867490 | 0.75 | HRH3 (0.42) | SRCMAPTSLC2A1ALDH1A1THRB | |
| SCHEMBL23867489 | 0.74 | MGLL (0.44) | SRCPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL23867551 | 0.73 | LMNA (0.61) | POLBMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31094233 | 0.73 | PKM (0.50) | MAPTSMN1; SMN2SLC2A1L3MBTL1ALDH1A1 | |
| SCHEMBL3645171 | 0.72 | HTR2C (0.58) | MAPTALDH1A1MEN1BLMKMT2A | |
| SCHEMBL27429987 | 0.70 | MAPT (0.48) | SRCMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23867516 | 0.70 | POLB (0.53) | POLBMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23867481 | 0.68 | HRH3 (0.51) | SRCMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |