Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PDE2A | O00408 | 3/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.49 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21756731 | 1.00 | MAPT (0.50) | MAPTTDP1PDE2ATAS1R3TAS1R1 | |
| SCHEMBL21756730 | 0.85 | NPC1 (0.52) | MAPTTDP1ALDH1A1MEN1NPC1 | |
| SCHEMBL21756726 | 0.85 | NPC1 (0.52) | MAPTTDP1ALDH1A1MEN1NPC1 | |
| SCHEMBL21756727 | 0.85 | NPC1 (0.52) | MAPTTDP1ALDH1A1MEN1NPC1 | |
| SCHEMBL16383898 | 0.83 | L3MBTL1 (0.58) | MAPTPDE2AACACBALDH1A1LMNA | |
| SCHEMBL1920569 | 0.77 | SMN1; SMN2 (0.42) | MAPTCNR1LMNA | |
| SCHEMBL28354065 | 0.76 | TAS1R3 (0.70) | TAS1R3TAS1R1ACACBALDH1A1MEN1 | |
| SCHEMBL21756738 | 0.74 | HPGD (0.55) | MAPTALDH1A1EGLN1MEN1NPC1 | |
| SCHEMBL3241450 | 0.73 | ALDH1A1 (0.69) | TAS1R3TAS1R1ACACBALDH1A1MEN1 | |
| SCHEMBL31739150 | 0.73 | ACACB (0.69) | MAPTTDP1PDE2ATAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043601-B2 | N-substituted-1H-1,2,4-triazole-3-carboxamides, analogues thereof, and methods of treatment using same | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2024-07-23 | — | — | US | disclosed |
| US-20210309618-A1 | N-SUBSTITUTED-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDES, ANALOGUES THEREOF, AND METHODS OF TREATMENT USING SAME | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309618-A1 | N-SUBSTITUTED-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDES, ANALOGUES THEREOF, AND METHODS OF TREATMENT USING SAME | BAK1, NAAA, CASP3 | MAPT 4808/4885TDP1 2707/4885PDE2A 1090/4885 |
| US-12043601-B2 | N-substituted-1H-1,2,4-triazole-3-carboxamides, analogues thereof, and methods of treatment using same | BAK1, NAAA, CASP3 | MAPT 4808/4885TDP1 2707/4885PDE2A 1090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.