Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 3/20 | 0.35 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8986948 | 0.91 | LMNA (0.33) | LMNAALDH1A1TSHRFGFR4CA1 | |
| Acrylic Acid SCHEMBL1082680 | 0.89 | LMNA (0.47) | LMNAALDH1A1TSHRFGFR4CA1 | |
| Acrylic Acid SCHEMBL819698 | 0.89 | LMNA (0.47) | LMNAALDH1A1TSHRFGFR4CA1 | |
| Acrylic Acid SCHEMBL16257 | 0.89 | — | — | |
| Fumaric Acid SCHEMBL23629433 | 0.88 | LMNA (0.59) | LMNAALDH1A1TSHRFGFR4CA1 | |
| Acrylic Acid SCHEMBL10632946 | 0.86 | CA4 (0.50) | LMNAALDH1A1TSHRFGFR4CA1 | |
| Acrylic Acid SCHEMBL21246904 | 0.86 | — | — | |
| Acrylic Acid SCHEMBL21246905 | 0.86 | LMNA (0.44) | LMNAALDH1A1TSHRFGFR4CA1 | |
| Acrylic Acid SCHEMBL9418472 | 0.86 | — | — | |
| Acrylic Acid SCHEMBL1367649 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110616575-A | Reactive dye for textile and environment-friendly salt-free dyeing process thereof | 万得化工科技(上海)有限公司 | 2019-12-27 | — | — | CN | claimed |
| EP-2162522-B1 | GRANULAR ENZYMATIC DETERGENT COMPOSITIONS | UNILEVER NV (NL) | 2018-07-04 | — | — | EP | claimed |
| EP-2162522-A1 | GRANULAR ENZYMATIC DETERGENT COMPOSITIONS | UNILEVER N.V. (NL) | 2010-03-17 | — | — | EP | claimed |
| JP-2009517330-A | — | — | 2009-04-30 | — | — | JP | claimed |
| WO-2009000605-A1 | GRANULAR ENZYMATIC DETERGENT COMPOSITIONS | UNILEVER N.V. (NL) | 2008-12-31 | — | — | WO | claimed |
| EP-1558717-B1 | LAUNDRY DETERGENT COMPOSITION | UNILEVER PLC (GB) | 2008-12-24 | — | — | EP | claimed |
| EP-1957619-A2 | COATED CALCIUM HYPOCHLORITE COMPOSITION | Arch Chemicals, Inc. (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007064681-A2 | COATED CALCIUM HYPOCHLORITE COMPOSITION | ARCH CHEMICALS, INC. (US) | 2007-06-07 | — | — | WO | claimed |
| US-20070125979-A1 | Coated calcium hypochlorite composition | INNOVATIVE WATER CARE, LLC | 2007-06-07 | — | — | US | claimed |
| US-7078373-B2 | Laundry detergent composition | UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC. (US) | 2006-07-18 | — | — | US | claimed |
| EP-1558717-A1 | LAUNDRY DETERGENT COMPOSITION | UNILEVER PLC (GB) | 2005-08-03 | — | — | EP | claimed |
| WO-2004041982-A1 | LAUNDRY DETERGENT COMPOSITION | UNILEVER PLC (GB) | 2004-05-21 | — | — | WO | claimed |
| US-20040097394-A1 | Laundry detergent composition | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2004-05-20 | — | — | US | claimed |
| US-6235149-B1 | Acrylic acid/maleic acid copolymers as detackification agents for adhesives contained in secondary fiber | VININGS INDUSTRIES, INC. | 2001-05-22 | — | — | US | claimed |
| WO-1999019559-A1 | POLYMERS AS DETACKIFICATION AGENTS FOR ADHESIVES CONTAINED IN SECONDARY FIBER | RHODIA CHIMIE (US) | 1999-04-22 | — | — | WO | claimed |
| US-20240237639-A1 | COMPOSITION WITH ENHANCED PLANT DISEASE CONTROL EFFECT AND RAINFASTNESS OF D-TAGATOSE | MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) | 2024-07-18 | — | — | US | disclosed |
| EP-4389885-A2 | ALPHA-AMYLASE VARIANTS | DANISCO US INC (US) | 2024-06-26 | — | — | EP | disclosed |
| EP-1558717-A1 | LAUNDRY DETERGENT COMPOSITION | UNILEVER PLC (GB) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041982-A1 | LAUNDRY DETERGENT COMPOSITION | UNILEVER PLC (GB) | 2004-05-21 | — | — | WO | disclosed |
| US-20040097394-A1 | Laundry detergent composition | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2004-05-20 | — | — | US | disclosed |